Results 271 to 280 of about 2,334,067 (354)

Long-Term Administration of Endothelin Receptor Antagonist Improves Coronary Endothelial Function in Patients With Early Atherosclerosis

Circulation, 2010
M. Reriani, E. Raichlin, A. Prasad, V. Mathew, Geralyn M. Pumper, Rebecca E. Nelson, R. Lennon, C. Rihal, L. Lerman, A. Lerman   +9 more
semanticscholar   +1 more source

Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling

British Journal of Pharmacology, Volume 182, Issue 12, Page 2585-2602, June 2025.
Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows, Kate Quigley, Venus Leung, Alexander J. Ainscough, Martin R. Wilkins, Harry Barnett, David Miller, Manuel Mayr, Beata Wojciak‐Stothard   +8 more
wiley   +1 more source

Cyclic Pentapeptide Endothelin A Receptor Antagonists with Attenuated in Vivo Clearance.

, 1996
Tatsuki Fukami, Kenji Niiyama, Y. Amano, Akihiro Hisaka, Naoko Fujino, Yoshio Sawasaki, M. Ihara, Kinji Ishikawa   +7 more
openalex   +2 more sources

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, Volume 42, Issue 6, June 2025.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 2920-2939, June 2025.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source

Expression of Endothelin-1, Endothelin-Converting Enzyme, and Endothelin Receptors in Chronic Heart Failure

, 1999
Oliver Zolk, Jessika Quattek, G. Sitzler, Thomas O. Schrader, Georg Nickenig, Petra Schnabel, Kohei Shimada, Masaaki Takahashi, Michael Böhm   +8 more
openalex   +1 more source

Cardioprotective and Anti‐Hypertensive Effects of Epigallocatechin Gallate: Novel Insights Into Biological Evidence

The Journal of Clinical Hypertension, Volume 27, Issue 6, June 2025.
ABSTRACT Epigallocatechin gallate (EGCG), the major catechin in green tea, is of considerable interest principally due to its proposed antihypertensive and cardioprotective properties. New research shows that EGCG can help relax the circulation of blood vessels, reduce arterial stiffness of arteries, and promote antioxidant activity promotion, which ...
Reza Eshraghi, Ashkan Bahrami, Faraz Tayyar Iravanlou, Mehdi Karimi, Mohammad Saeed Soleimani, Mohammad Hossein Paknahad, Mohammad Yaghoubi, Arman Beheshtirooy, Fatemeh Qasemi Talouki, Javad Shaabanzadeh, Fatemeh Hasani, Alireza Rafi, Mohammad Hossein Pourhanifeh   +12 more
wiley   +1 more source

Multiomics‐Driven Drug‐Cell Interaction Network for Chemotherapy Sensitivity Prediction in Metabolically Defined Triple‐Negative Breast Cancer Subtypes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Triple‐negative breast cancer (TNBC) is associated with a poor prognosis due to insufficient molecular subtyping precision and limited actionable targets. Although metabolic reprogramming underlies TNBC chemotherapy resistance, establishing metabolic subtyping systems and investigating drug sensitivity across distinct metabolic subgroups could
Jingyuan Zhang, Xuejun Sun
wiley   +1 more source