Results 281 to 290 of about 2,334,067 (354)

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, Volume 52, Issue 6, Page e430-e480, June 2025.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes

Physiological Reports, Volume 13, Issue 12, June 2025.
Abstract Pericytes contract during acute myocardial infarction (AMI) resulting in capillary constriction, which further contributes to the ischemic damage and enlargement of infarct size. We hypothesized that increased intramyocardial pressure during ischemia can be sensed by mechanosensitive Transient Receptor Potential (TRP) channels in cardiac ...
Carmen Methner, Eugene Cilento, Zhiping Cao, Jeffrey Iliff, Anusha Mishra, Sanjiv Kaul   +5 more
wiley   +1 more source

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Endothelin receptor antagonists

Pharmacology & Therapeutics, 2006
Endothelin receptor antagonists (ERAs) have been developed to block the effects of endothelin-1 (ET-1) in a variety of cardiovascular conditions. ET-1 is a powerful vasoconstrictor with mitogenic or co-mitogenic properties, which acts through the stimulation of 2 subtypes of receptors [endothelin receptor subtype A (ETA) and endothelin receptor subtype
Motte, Sophie, McEntee, Kathleen, Naeije, Robert   +2 more
openaire   +5 more sources

The endothelin system and endothelin receptor antagonists

Current Opinion in Nephrology & Hypertension, 2012
There is increasing evidence that endothelin receptor blockade and, in particular, ET(A) receptor blockade not only confers protection against proteinuric renal disease in diabetes but also confers vasculoprotection.Recent clinical trials using ET(A) receptor blockade in treating proteinuria and chronic kidney disease as well as atherosclerosis show ...
Anna M.D. Watson, Karin Jandeleit-Dahm
openaire   +3 more sources

Endothelin and endothelin receptors A and B in the human testis [PDF]

Anatomy and Embryology, 1999
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
Süleyman Ergün, H. J. Paust, S. Harneit, Amal K. Mukhopadhyay, Adolf F. Holstein   +4 more
openaire   +2 more sources

Biotinylated endothelin as a probe for the endothelin receptor

Peptides, 1991
Biotinylated derivatives of endothelin (ET)-1 were prepared by chemical modification of ET-1 with sulfosuccinimidyl 6-(biotinamido) hexanoate. Two major biotinylated ET analogs were purified by reversed-phase high performance liquid chromatography.
Eli Hazum, Iris Schvartz, Gerry Gitlin, Olivia Ittoop, Tany Amarant   +4 more
openaire   +3 more sources

Heterogeneity of Endothelin Receptor

Journal of Cardiovascular Pharmacology, 1991
The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight of ET binding protein) and ...
Yasuhiro Furuichi, Takahide Watanabe, Tsuyoshi Takasuka, Naoko Satoh, Ikuo Horii   +4 more
openaire   +3 more sources

Development of a Photolabile Ligand for the Endothelin-A Receptor of Endothelin

Journal of Cardiovascular Pharmacology, 2000
Actions of endothelin (ET) are usually mediated through the so-called endothelin-A or -B (ET(A) or ET(B))-receptors. As part of our ongoing research program, we are studying the characterization of the ET(A)-receptor using specific photolabile ligands.
S Tessier, A. De Lean, Alain Fournier, Alexandre Brkovic, M Coupal, C Langlois   +5 more
openaire   +3 more sources

Endothelin and Endothelin Receptor Antagonism in Heart Failure

Journal of Cardiovascular Pharmacology, 2000
Endothelin (ET)-1 is a potent vasoconstrictor with growth promoting and mitogenic properties associated with various cardiovascular diseases (CVD) and has been found to be an important protagonist in congestive heart failure (CHF). The introduction of ET-1 receptor antagonists into the arena of clinical research has amplified our understanding of the ...
Wolfgang Kiowski, Gabor Sütsch
openaire   +3 more sources