Results 21 to 30 of about 2,437,403 (392)
Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]
, 2008 Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato +42 more
core +3 more sources
Pulmonary Circulation, 2020 Many patients with pulmonary arterial hypertension do not achieve treatment goals with monotherapy, and therefore combination therapy is becoming the standard of care.
Hossein-Ardeschir Ghofrani +10 more
doaj +1 more source
BMC Neuroscience, 2007 Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter +3 more
doaj +1 more source
Affinity labelling of endothelin receptor and characterization of solubilized endothelin–endothelin‐receptor complex [PDF]
European Journal of Biochemistry, 1990 Chick cardiac membranes were affinity labelled by cross‐linking to membrane‐bound 125I‐endothelin‐1 with disuccinimidyl tartarate. SDS/PAGE and autoradiographic analysis of the 125I‐endothelin‐1‐labelled material in the presence or absence of 2‐mercaptoethanol revealed one major labelled band, corresponding to a molecular mass of 53 kDa, whose ...
H, Miyazaki +9 more
openaire +2 more sources
Pharmacological Potential of Endothelin Receptors Agonists and Antagonists
Acta Medica, 2005 Endothelins are potent predominantly vasoconstricting agents that act as local autocrine and paracrine mediators. Endothelin-1 is the most potent and sustained vasoconstrictor and pressor substance yet identified.
Jiří Patočka +3 more
doaj +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Endothelin Receptors and Pain [PDF]
The Journal of Pain, 2009 The endogenous endothelin (ET) peptides participate in a remarkable variety of pain-relatedprocesses. Pain that is elevated by inflammation, by skin incision, by cancer, during a Sickle Cell Disease crisis and by treatments that mimic neuropathic and inflammatory pain and are all reduced by local administration of antagonists of endothelin receptors ...
Khodorova, Alla +2 more
openaire +3 more sources
Acta Dermato-Venereologica, 2019 Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong +9 more
doaj +1 more source
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension
Frontiers in Immunology, 2022 IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling +30 more
doaj +1 more source
Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
EMBO Molecular Medicine, 2017 Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations ...
Michael P. Smith +20 more
semanticscholar +1 more source