Results 41 to 50 of about 2,334,067 (354)
PLoS ONE, 2015 IntroductionPrevious studies have suggested that cerebrospinal fluid from patients with subarachnoid hemorrhage (SAH) leads to pronounced vasoconstriction in isolated arteries.
Barbara Assenzio +11 more
doaj +1 more source
Nature Communications, 2018 Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB ...
Wataru Shihoya +8 more
doaj +1 more source
Endothelin type A receptors mediate pain in a mouse model of sickle cell disease
Haematologica, 2018 Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease.
Brianna Marie Lutz +7 more
doaj +1 more source
Pulmonary hypertension: reasonable selection of specific therapy [PDF]
Системные гипертензии, 2018 Pulmonary hypertension is characterized with persistent increase in pulmonary vascular resistance leading to progressive worsening of right ventricular failure and death.
N A Karoli, S I Sazhnova, A P Rebrov
doaj +1 more source
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Archivum Immunologiae et Therapiae Experimentalis, 2014 Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB.
A. Kowalczyk +4 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2018 Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological
Jan Polak +3 more
doaj +1 more source
Endothelin receptor signaling: new insight into its regulatory mechanisms.
Journal of Pharmacological Sciences, 2013 The endothelin (ET) system consists of two G protein coupled-receptors (GPCRs), ET type A receptor (ETAR) and ET type B receptor (ETBR), and three endogenous ligands, ET-1, ET-2, and ET-3.
T. Horinouchi +3 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
Endothelin receptor antagonism and cancer [PDF]
European Journal of Clinical Investigation, 2009 AbstractThe endothelin peptides have an important role in the cancer‐stromal interactions that promote tumour growth. Endothelin‐1 (ET‐1), clinically the most investigated endothelin, is a vital agent in the growth and progression of several tumours including prostate, ovarian, colorectal, bladder, breast and lung carcinomas.
Marc C. Winslet +4 more
openaire +3 more sources
Endothelin receptor antagonists for pulmonary arterial hypertension.
Cochrane Database of Systematic Reviews, 2013 BACKGROUND Pulmonary arterial hypertension is a devastating disease, which leads to right heart failure and premature death. Recent evidence suggests that endothelin receptor antagonists may be promising drugs in the treatment of pulmonary arterial ...
Chao Liu +4 more
semanticscholar +1 more source