Results 121 to 130 of about 304,614 (388)

Pulmonary arterial hypertension: diagnosis and treatment

Studia Medyczne, 2013
Pulmonary arterial hypertension is one of the clinical groups of arterial hypertension. It is a rare, chronic disease with a very poor prognosis.
Marcin Sadowski, Agnieszka Janion-Sadowska, Agnieszka Łętek, Grzegorz Raczyński, Łukasz Zandecki   +4 more
doaj   +1 more source

Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension [PDF]

, 2010
Resistant hypertension is defined as failure to lower blood pressure to target when a patient adheres to the maximum tolerated doses of three antihypertensive drugs including a diuretic.
Enseleit, F, Lüscher, T F, Ruschitzka, F   +2 more
core   +1 more source

Cardiovascular magnetic resonance‐estimated pulmonary capillary wedge pressure, congestion markers, and effect of empagliflozin in patients with heart failure with reduced ejection fraction and dysglycaemia (SUGAR‐DM‐HF)

European Journal of Heart Failure, EarlyView.
Abstract Aims A cardiovascular magnetic resonance (CMR) approach to non‐invasively estimate left ventricular (LV) filling pressure was recently developed and shown to correlate with invasively measured pulmonary capillary wedge pressure (PCWP). We examined the association between CMR‐estimated PCWP (CMR‐PCWP) and other imaging and biomarker measures of
Joanna Osmanska, Kieran F. Docherty, Colin Berry, Pardeep S. Jhund, Kenneth Mangion, Patrick B. Mark, John J.V. McMurray, Giles Roditi, Naveed Sattar, Mark C. Petrie, Ross T. Campbell, Matthew M.Y. Lee   +11 more
wiley   +1 more source

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, EarlyView.
Among high‐risk patients with T2D, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. ABSTRACT Aims The sodium–glucose cotransporter 2 inhibitor canagliflozin reduces the risk of heart failure (HF ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis. [PDF]

, 2016
The endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for therapeutic intervention in human diseases. Endothelin-receptor antagonists are in clinical use to treat pulmonary arterial hypertension and have been under ...
Battistini B., Berger Y., Clozel M., Clozel M., Hoshino T., John-David Aubert, King T. E., Kusuhara M., Langleben D., Lucienne Juillerat-Jeanneret, Nambi P., Ohlstein E. H., Shyamala V., Tabrizchi R.   +13 more
core   +1 more source

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

European Journal of Organic Chemistry, EarlyView.
Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach

Journal of Pharmacological Sciences, 2003
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura, Shoshiro Okada, Kunihiko Yokotani   +2 more
doaj  

Relationship between cellular response and behavioral variability in bacterial chemotaxis [PDF]

, 2007
Bacterial chemotaxis in Escherichia coli is a canonical system for the study of signal transduction. A remarkable feature of this system is the coexistence of precise adaptation in population with large fluctuating cellular behavior in single cells (Korobkova et al. 2004, Nature, 428, 574).
arxiv   +1 more source

Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension.

Circulation, 2000
BACKGROUND Few treatments are available for isolated pulmonary hypertension (PHT), which has a high morbidity and mortality. This trial was designed to assess the hemodynamic effects of bosentan, an endothelin receptor antagonist, in patients with PHT ...
D. Williamson, Lucinda L. Wallman, Richard Jones, A. Keogh, Frances Scroope, R. Penny, C. Weber, P. Macdonald   +7 more
semanticscholar   +1 more source

Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]

, 2014
Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core   +3 more sources