Results 141 to 150 of about 18,729 (264)

The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial

Diabetologia, 2012
A. Rafnsson, F. Böhm, Magnus Settergren, A. Gonon, Kerstin Brismar, John Pernow   +5 more
semanticscholar   +1 more source

HJP 272, an endothelin receptor antagonist, and its role in cancer cell migration and invasion. [PDF]

Transl Oncol
Baig N, Chilamakuri R, Agarwal S, Muth A, Reznik SE.   +4 more
europepmc   +1 more source

Crataegus oxyacantha Extract Enhances Cardiac Adaptation and Reduces Oxidative‐Inflammatory Stress in Broiler Chickens Raised at High Altitude Under Cold Stress

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Crataegus oxyacantha extract at 0.4 mL/L improved cardiac function in broilers under cold stress and high altitude by increasing nitric oxide synthase gene expression, boosting nitric oxide, reducing endothelin‐1 gene expression, and lowering oxidative‐inflammatory stress, offering a natural solution to mitigate pulmonary hypertension syndrome ...
Behnam Ahmadipour, Hossein Hassanpour, Samira Abaszadeh, Majid Kalantar   +3 more
wiley   +1 more source

Exploring patient preferences regarding the use of combination therapy with endothelin receptor antagonist (ERA) + phosphodiesterase-5 inhibitors (PDE5i). [PDF]

JHLT Open
Kolaitis NA, Kingman M, Wilson M, Rendon GG, Lopez D, Paoli CJ, Rahman M, Martin A, McGarvey N, Lee A, Mirza S, Melendres-Groves L.   +11 more
europepmc   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Exploring Providers' Behaviors, Attitudes, and Preferences on the Treatment of Pulmonary Arterial Hypertension With Endothelin Receptor Antagonist (ERA) + Phosphodiesterase-5 Inhibitors (PDE5i). [PDF]

Pulm Circ
Kolaitis NA, Kingman M, Wilson M, Rendon GG, Lopez D, Paoli CJ, Rahman M, Martin A, McGarvey N, Lee A, Melendres-Groves L.   +10 more
europepmc   +1 more source

Endothelin Receptor Antagonists [PDF]

Cardiovascular Drug Reviews, 1994
openaire   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, Volume 183, Issue 13, Page 3762-3779, July 2026.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.

Journal of Medicinal Chemistry, 2012
M. Bolli, C. Boss, C. Binkert, Stephan Buchmann, D. Bur, P. Hess, M. Iglarz, Solange Meyer, Josiane Rein, Markus Rey, A. Treiber, M. Clozel, W. Fischli, T. Weller   +13 more
semanticscholar   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source