Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment. [PDF]
Sci Rep, 2022 Fontes MSC +4 more
europepmc +1 more source
The therapeutic role of exercise training during menopause for reducing vascular disease
Experimental Physiology, EarlyView.Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing +4 more
wiley +1 more source
Derivatives of an endothelin A receptor antagonist for PET imaging [PDF]
, 2011 openalex +1 more source
Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage [PDF]
, 2022 Aurélie Cullier +13 more
openalex +1 more source
Experimental Physiology, EarlyView.Abstract Over the past three decades, there has been a steady increase in clinical attention to ischaemic heart failure caused by coronary microembolization. Nonetheless, a suitable mouse model for studying this condition remains limited. In the present study, we developed a mouse model of coronary microembolization‐induced ischaemic heart failure by ...
Lang Pei +10 more
wiley +1 more source
Aprocitentan, A Dual Endothelin Receptor Antagonist Under Development for the Treatment of Resistant Hypertension. [PDF]
Cardiol Ther, 2021 Angeli F, Verdecchia P, Reboldi G.
europepmc +1 more source
B1 Effect of chronic treatment with two different ETA-selective endothelin receptor antagonists on blood pressure and small artery structure of docasalt hypertensive rats [PDF]
, 1997 J LI
openalex +1 more source
Experimental Physiology, EarlyView.Abstract Human populations native to high altitude have evolved distinct physiological adaptations to chronic hypoxia. This adaptation is evident in the O2 transport cascade. In this review, with brief inclusion of the related genetic adaptations, we compare the O2 cascade across three well‐characterized high‐altitude populations: Andeans (Aymara and ...
Ayechew A. Getu +5 more
wiley +1 more source
Urotensin II-Induced Increase in Myocardial Distensibility Is Modulated by Angiotensin II and Endothelin-1 [PDF]
, 2009 Endogenous regulators, such as angiotensin-II (AngII), endothelin-1 (ET-1) and urotensin-II (U-II) are released from various cell types and their plasma levels are elevated in several cardiovascular diseases.
Fontes-Sousa AP +3 more
core
Experimental Physiology, EarlyView.Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir +5 more
wiley +1 more source