Medication adherence, hospitalization, and healthcare resource utilization and costs in patients with pulmonary arterial hypertension treated with endothelin receptor antagonists or phosphodiesterase type-5 inhibitors [PDF]
Pulmonary Circulation, 2020 Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited.
Robert P. Frantz +6 more
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The role of endothelin receptor antagonists in kidney disease [PDF]
Renal FailureKidney diseases are among the most prevalent conditions worldwide, impacting over 850 million individuals. They are categorized into acute kidney injury and chronic kidney disease. Current preclinical and clinical trials have demonstrated that endothelin
Xiaoting Ma +5 more
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Clinicians' preferences for managing aneurysmal subarachnoid hemorrhage using endothelin receptor antagonists [PDF]
Frontiers in Neurology, 2023 BackgroundThe endothelin receptor antagonist (ERA) clazosentan is being investigated for the medical prevention of cerebral vasospasm and associated complications, such as delayed cerebral ischemia (DCI), after aneurysmal subarachnoid hemorrhage (aSAH ...
Sebastian Heidenreich +3 more
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Endothelin receptor antagonists (ERAs) can potentially be used as therapeutic drugs to reduce hypertension caused by small molecule tyrosine kinase inhibitors (TKIs) [PDF]
Frontiers in PharmacologyThe emergence of targeted anti-tumor drugs has significantly prolonged the lifespan and improved the prognosis of cancer patients. Among these drugs, vascular endothelial growth factor (VEGF) inhibitors, particularly novel small molecule tyrosine kinase ...
Qingjian He +11 more
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Endothelin-receptor antagonists in the management of pulmonary arterial hypertension: where do we stand? [PDF]
Vascular Health and Risk Management, 2018 Michele Correale,1 Armando Ferraretti,2 Ilenia Monaco,3 Davide Grazioli,1 Matteo Di Biase,4 Natale Daniele Brunetti3 1Department of Cardiology, Ospedali Riuniti University Hospital, Foggia, 2Cardiology Unit, “Caduti in guerra” Hospital ...
Correale M +5 more
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Clinical and hemodynamic effect of endothelin receptor antagonists in eisenmenger syndrome
Annals of Pediatric Cardiology, 2020 Introduction: Endothelin receptor antagonists (ERAs) are widely accepted as a specific treatment for pulmonary arterial hypertension. Unfortunately, consensus and recommendations are lacking for the treatment of patients who suffer from pulmonary ...
Emir Yonas +6 more
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Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction [PDF]
Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood +11 more
wiley +2 more sources
Pulmonary hypertension: reasonable selection of specific therapy [PDF]
Системные гипертензии, 2018 Pulmonary hypertension is characterized with persistent increase in pulmonary vascular resistance leading to progressive worsening of right ventricular failure and death.
N A Karoli, S I Sazhnova, A P Rebrov
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Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. [PDF]
PLoS ONE, 2012 Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and ...
John Gatfield +4 more
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Endothelin increases the proliferation of rat olfactory mucosa cells
Neural Regeneration Research, 2020 The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life.
Bertrand Bryche +5 more
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