Results 21 to 30 of about 285,474 (314)
Endothelin receptor antagonists for pulmonary arterial hypertension. [PDF]
Cochrane Database of Systematic Reviews, 2013 Chao Liu +4 more
semanticscholar +2 more sources
Endothelin receptor antagonists for the treatment of diabetic and nondiabetic chronic kidney disease
Current opinion in nephrology and hypertension, 2021 Purpose of review To summarize new clinical findings of endothelin receptor antagonists (ERA) in various etiologies of kidney disease targeted in clinical trials.
David Smeijer +4 more
semanticscholar +1 more source
Endothelin increases the proliferation of rat olfactory mucosa cells
Neural Regeneration Research, 2020 The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life.
Bertrand Bryche +5 more
doaj +1 more source
Endothelins and liver cirrhosis
Portal Hypertension & Cirrhosis, 2022 Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
doaj +1 more source
Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going
Biology, 2022 Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous ...
Andreas Haryono +3 more
doaj +1 more source
Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
BMC Cancer, 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed.
Suhas Vasaikar +17 more
doaj +1 more source
Евразийский Кардиологический Журнал, 2017 Idiopathic pulmonary hypertension (IPAH) is a rare cardiovascular disease of unknown etiology, but the most common form of pulmonary arterial hypertension, defined as mean pulmonary arterial pressure >25 mmHg and pulmonary vascular resistance >3 ...
G. A. Movsisyan +6 more
doaj +1 more source
Endothelin Receptors and Their Antagonists
Seminars in Nephrology, 2015 All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
Maguire, Janet J, Davenport, Anthony P
openaire +3 more sources
The use of Macitentan in Fontan circulation: a case report
BMC Cardiovascular Disorders, 2017 Background The Fontan circulation, a result of a palliative procedure in patients with single systemic ventricles, is defined by chronically elevated pulmonary vascular resistance.
Polyvios Demetriades +4 more
doaj +1 more source
Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source