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Endothelin receptor antagonists for the treatment of pulmonary artery hypertension [PDF]
AimsThe demonstration that endothelin production is upregulated in pulmonary artery hypertension (PAH) served as the rationale for developing endothelin-receptor antagonists (ERAs) as a treatment for PAH.
Komaromy, David+5 more
core +2 more sources
Clinical and hemodynamic effect of endothelin receptor antagonists in eisenmenger syndrome
Introduction: Endothelin receptor antagonists (ERAs) are widely accepted as a specific treatment for pulmonary arterial hypertension. Unfortunately, consensus and recommendations are lacking for the treatment of patients who suffer from pulmonary ...
Emir Yonas+6 more
doaj +2 more sources
Evidence for biased agonists and antagonists at the endothelin receptors. [PDF]
Biased ligands represent a new strategy for the development of more effective and better tolerated drugs. To date there has been a paucity of research exploring the potential of ligands that exhibit either G protein or β-arrestin pathway selectivity at ...
Maguire, Janet J
core +10 more sources
Endothelin receptor antagonists for pulmonary arterial hypertension. [PDF]
Pulmonary arterial hypertension is a devastating disease that leads to right heart failure and premature death. Endothelin receptor antagonists have shown efficacy in the treatment of pulmonary arterial hypertension.To evaluate the efficacy of endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension.We searched the Cochrane Central ...
Liu C, Chen J, Gao Y, Deng B, Liu K.
europepmc +7 more sources
Endothelin receptor antagonists for the treatment of diabetic and nondiabetic chronic kidney disease
Purpose of review To summarize new clinical findings of endothelin receptor antagonists (ERA) in various etiologies of kidney disease targeted in clinical trials.
David Smeijer+4 more
semanticscholar +1 more source
Endothelin-Receptor Antagonists in Uremic Cardiomyopathy
Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure. These correlate with the severity of renal failure. Patients with elevated ET-1 concentrations show an increased cardiovascular mortality. The prevalence of severe left ventricular hypertrophy (LVH) is a very important factor for survival and morbidity in uremic ...
Sabine Wolf+6 more
openalex +4 more sources
Endothelin increases the proliferation of rat olfactory mucosa cells
The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life.
Bertrand Bryche+5 more
doaj +1 more source
Endothelins and liver cirrhosis
Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
doaj +1 more source
Endothelin and the ischaemic heart [PDF]
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
Kane, K.A., McCabe, C., Wainwright, C.L.
core +1 more source
Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going
Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous ...
Andreas Haryono+3 more
doaj +1 more source