Results 61 to 70 of about 15,820 (232)

The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses

European Respiratory Review, 2009
Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location.
J-L Vachiéry, A. Davenport
doaj  

The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs

International Journal of Analytical Chemistry, 2018
Hypertension or high blood pressure is a harbinger of cardiovascular diseases. There are several classes of drugs used to treat hypertension. This review discusses the use of dried blood spots (DBSs) for the quantification by mass spectrometry (MS ...
Alexander Chernonosov
doaj   +1 more source

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor

BMC Cancer, 2008
Background Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35, with two ...
Patterson Paul H, Montgomery Jennifer P
doaj   +1 more source

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source

Opportunities and challenges in the treatment of IgA nephropathy

Frontiers in Pharmacology
The treatment paradigm of immunoglobulin A nephropathy (IgAN) is shifting, and traditional therapeutic strategies are insufficient to meet clinical needs.
Yang Yang, Yang Yang, Gaosi Xu
doaj   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension

Respiratory Research, 2011
Background Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Brandes Ralf P, Janssen Wiebke, Cornitescu Teodora, Sydykov Akylbek, Dahal Bhola K, Luitel Himal, Kojonazarov Baktybek, Kosanovic Djuro, Davie Neil, Ghofrani Hossein A, Weissmann Norbert, Grimminger Friedrich, Seeger Werner, Schermuly Ralph T   +13 more
doaj   +1 more source

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Children with congenital heart disease (CHD) frequently undergo cardiac magnetic resonance imaging (MRI) under anesthesia. Although these procedures lack surgical stimulus, patients remain physiologically vulnerable, and the incidence of perioperative cardiovascular instability in this setting is poorly defined.
Theodora Wingert, Justine Liang, Kelly Feldman, Amelie Delaporte, Christine Nguyen‐Buckley, Tristan Grogan, Alexandre Joosten, John Paul Finn, Ihab Ayad   +8 more
wiley   +1 more source

Therapy of IgA nephropathy: time for a paradigm change

Frontiers in Medicine
Immunoglobulin A nephropathy (IgAN) often has a poor outcome, with many patients reaching kidney failure within their lifetime. Therefore, the primary goal for the treatment of IgAN should be to reduce nephron loss from the moment of diagnosis.
Jonathan Barratt, Richard A. Lafayette, Jürgen Floege   +2 more
doaj   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source