Results 11 to 20 of about 19,945 (215)

Spatiotemporal gene targeting in the mouse corneal endothelium

Taiwan Journal of Ophthalmology, 2023
PURPOSE: The inducible Cre-ERT2 recombinase system allows for temporal control of gene targeting, and it is useful to studying adult function of genes that have critical developmental roles.
JeongGoo Lee, Martin Heur
doaj   +1 more source

Generation of a Novel Col8a2^P2A-CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation. [PDF]

Genesis
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yuan Y, Holt J, Lorry S, Wang YC, Hu YC, Ma Z, Kaufman A, Kao W, Ogando DG, Liu CY.   +9 more
europepmc   +2 more sources

Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium

Advanced Science, 2022
Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its ...
Eleonora Maurizi, Davide Alessandro Martella, Davide Schiroli, Alessia Merra, Salman Ahmad Mustfa, Graziella Pellegrini, Claudio Macaluso, Ciro Chiappini   +7 more
doaj   +1 more source

Specular microscopy of the corneal endothelial cells of bovines: An ex vivo study

Open Veterinary Journal, 2023
Background: The endothelium is the most posterior layer of the cornea and essential for maintaining corneal transparency. Due to variations in corneal endothelial parameters among different species, knowledge of the normal parameters for each species is
Mariane Gallicchio Azevedo, Natalia Pons Mendez, Luísa Soares Cargnin, Rafaella Silva Rocha, Maiara Poersch Seibel, Alessandra Fernandez da Silva, Joao Antonio Tadeu Pigatto   +6 more
doaj   +1 more source

Substrates for Expansion of Corneal Endothelial Cells towards Bioengineering of Human Corneal Endothelium

Journal of Functional Biomaterials, 2015
Corneal endothelium is a single layer of specialized cells that lines the posterior surface of cornea and maintains corneal hydration and corneal transparency essential for vision.
Jesintha Navaratnam, Tor P. Utheim, Vinagolu K. Rajasekhar, Aboulghassem Shahdadfar   +3 more
doaj   +1 more source

Comparison of Corneal Endothelium in Patients with Uveitis and Healthy Subjects Using Specular Microscopy

Pakistan Armed Forces Medical Journal, 2022
Objective: To evaluate changes in corneal endothelium in patients with anterior uveitis by using specular microscopy and compare it with the corneal endothelium of healthy subjects. Study Design: Comparative cross-sectional study.
Qurat ul Ain Ghazanfar, Omar Zafar, Noman Nazir Ahmed, Muhammad Manzoor Awan   +3 more
doaj   +1 more source

Constructing a Novel Three-Dimensional Biomimetic Corneal Endothelium Graft by Culturing Corneal Endothelium Cells on Compressed Collagen Gels

Chinese Medical Journal, 2018
Background: Endothelium allotransplantation is the primary treatment for corneal decompensation. The worldwide shortage of donor corneal tissue has led to increasing pressure to seek an alternative for surgical restoration of corneal endothelium ...
Yu-Jie Cen, Yun Feng
doaj   +1 more source

Factors affecting the corneal endothelium after selective laser trabeculoplasty in primary open angle and angle closure glaucoma

BMJ Open Ophthalmology, 2021
Purpose To study the factors affecting the corneal endothelium after selective laser trabeculoplasty (SLT) in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG).Method This prospective interventional study included 56 patients ...
Natalia Ivanovna Kurysheva, Lyudmila Vyacheslavovna Lepeshkina, Svetlana Georgievna Kapkova   +2 more
doaj   +1 more source

Histomorphometrical and histochemical postnatal development of cornea in indigenous rabbits [PDF]

Iraqi Journal of Veterinary Sciences, 2022
The present study aims to clarify corneal development via analyzing of the histomorphologic and some histochemical parameters in local rabbits. Samples were collected from 25 Rabbits divided into five different age groups at 1, 10, 15, 30, and 40 ...
Omar Y. Altaay, Ammar G. Al-Haaik
doaj   +1 more source

The Multifarious Effects of Various Glaucoma Pharmacotherapy on Corneal Endothelium: A Narrative Review

Ophthalmology and Therapy, 2023
Corneal endothelium is a single cell layer that is mainly responsible for maintaining corneal clarity. Endothelial damage secondary to toxicity, stress, or genetic predisposition are common and in conjunction with the low regenerative ability of the ...
Stylianos A. Kandarakis, Konstantina A. Togka, Leonidas Doumazos, Ioanna Mylona, Andreas Katsimpris, Petros Petrou, George Kymionis   +6 more
doaj   +1 more source