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Gene Delivery to the Corneal Endothelium

American Journal of Respiratory and Critical Care Medicine, 2000
Abstract Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.
ORAL, HALUK BARBAROS   +14 more
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Photography of the Corneal Endothelium

International Ophthalmology Clinics, 1976
Excellent photographs of corneal endothelial cells may be obtained during clinical examinations with the specular microscope. Endothelial photographs are extremely useful in documenting the corneal effects of ocular trauma, aging, inflammation, and surgery.
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Corneal Endothelium and Phacoemulsification

Cornea, 2016
Phacoemulsification has become the most commonly used procedure in cataract surgery owing to the development of new devices and surgical techniques; however, corneal endothelial damage still represents a serious complication. Although several factors are known to cause corneal endothelial damage, effects of irrigating pressure and temperature rise in ...
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Ionic channels in corneal endothelium

American Journal of Physiology-Cell Physiology, 1996
Single-channel patch-clamp techniques as well as standard and perforated-patch whole cell voltage-clamp techniques have been applied to the study of ionic channels in the corneal endothelium of several species. These studies have revealed two major K+ currents.
J L, Rae, M A, Watsky
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THE HEALING OF RABBIT CORNEAL ENDOTHELIUM

Acta Ophthalmologica, 1984
A circular 4 mm endothelial defect was induced by transcorneal freezing. The experimental damage and the healing took place in the living rabbit in 15 eyes, and in the isolated cornea in organ culture in further 20 eyes. The reparative process was studied by SEM, and proved to be the same in vivo and in vitro.
E G, Olsen, M, Davanger
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Effect of Urokinase on Corneal Endothelium

Archives of Ophthalmology, 1980
Urokinase in concentrations ranging from 1,000 to 5,000 units/mL was used to perfuse the corneal endothelium of rabbits for three hours in the specular microscope. No notable corneal swelling was noted, and the corneal endothelium appeared normal when observed with scanning electron microscopy.
D S, Hull, K, Green
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The Other Side of the Corneal Endothelium

Cornea, 1990
New high-magnification biomicroscopes, the specular microscope and now the in-tandem confocal microscope, provide new images of the corneal endothelium in vivo. These are not always easy to interpret, and correlation with the morphology of the endothelium as seen in dead, fixed specimens is necessary.
E S, Sherrard, Y L, Ng
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The Effect of Fluorouracil on the Corneal Endothelium

Archives of Ophthalmology, 1988
The utility of the antiproliferative agent fluorouracil has been demonstrated recently in glaucoma-filtering surgery and in the management of proliferative vitreoretinopathy after vitrectomy. Because of the potential for contact with the corneal endothelium, its toxicity to the endothelium is an important consideration.
M J, Mannis, E H, Sweet, R A, Lewis
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Pathology of Corneal Endothelium in Keratoconus

Ophthalmologica, 2010
Keratoconus is characterized by stromal thinning and conical deformity of the cornea that affects a small but significant portion of the population. Although keratoconus has been well studied, endothehal changes have not been extensively investigated.
C W, Sturbaum, R L, Peiffer
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Pinocytosis in the Rabbit Corneal Endothelium

Archives of Ophthalmology, 1961
Introduction In view of the demonstration that rabbit corneal epithelium actively transports sodium, 1,2 a preliminary electron microscopic study of this structure was undertaken. Previous electron microscopic studies had been primarily concerned with the characterization of the fibrous components of the cornea, and the specialized staining used to ...
A, DONN   +3 more
openaire   +2 more sources

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