Results 131 to 140 of about 599,728 (386)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial Endothelial function of normotensive adolescents with no risk factors for arterial hypertension

Jornal de Pediatria, 2005
OBJETIVO: Definir padrões de normalidade da função endotelial de adolescentes através de avaliação ultra-sonográfica da dilatação vascular dependente do endotélio.
Zélia M. de Andrade, João T. A. Carvalhaes, José A. A. C. Taddei, Dejaldo M. J. Christofalo, Sergio A. Ajzen   +4 more
doaj   +1 more source

Hemogenic Endothelium

Blood, 2010
Abstract Abstract SCI-44 Hematopoietic stem cells (HSCs) develop from endothelium in the midgestation mouse conceptus, starting at 10.5 days post coitus, through the formation of intra-aortic clusters. Studies in mouse, zebrafish, chick, and frog embryos established that Runx1 (AML1) is the earliest specific marker of the ...
Speck, N, Tober, J, Chen, M, De Bruijn, M, Chan, M   +4 more
openaire   +2 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses

Frontiers in Physiology, 2019
Hyperglycemia is a critical factor in the development of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Whether hyperglycemic states result in a disruption of similar molecular mechanisms in endothelial cells under both diabetic and non ...
Dhanush Haspula, Dhanush Haspula, Andrew K. Vallejos, Andrew K. Vallejos, Timothy M. Moore, Namrata Tomar, Ranjan K. Dash, Ranjan K. Dash, Brian R. Hoffmann, Brian R. Hoffmann, Brian R. Hoffmann, Brian R. Hoffmann, Brian R. Hoffmann   +12 more
doaj   +1 more source

Local Regulation of Arterial Tone: an Insight into Wall Dynamics Using Mathematical Models [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Boileau, E, Nithiarasu, P, Parthimos, D   +3 more
core  

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

FEBS Open Bio, EarlyView.
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian, Di Liu, Bing Liu, Yu Lan, Jie Zhou   +4 more
wiley   +1 more source

Multi-scale interaction of flow and the artery wall [PDF]

, 2009
We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying their widely separated spatial and temporal scales which participate.
2nd Micro and Nano Flows Conference (MNF2009), Atherton, MA, Care, CM, Collins, MW, Evans, D, Evans, PC, Halliday, I, Hose, DR, Khir, A, Krams, R, Lawford, PV, Lishchuk, SV, Ridger, V, Ventikos, Y, Walker, DC, Watton, PN   +15 more
core  

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Hematopoietic stem cells derive directly from aortic endothelium during development

Nature, 2009
A major goal of regenerative medicine is to instruct formation of multipotent, tissue-specific stem cells from induced pluripotent stem cells (iPSCs) for cell replacement therapies.
Julien Y. Bertrand, N. Chi, B. Santoso, Shutian Teng, D. Stainier, D. Traver   +5 more
semanticscholar   +1 more source