Results 171 to 180 of about 599,728 (386)
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
Contractile proteins in retinal endothelium and other non-muscle tissues of the eye. [PDF]
A H Rahi, Nicholas W. Ashton
openalex +1 more source
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang+6 more
wiley +1 more source
The anti-atherogenic effects of thiazolidinediones [PDF]
The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy+2 more
core
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
D. Fulton+8 more
semanticscholar +1 more source
The concentrations of sugar nucleotides in bovine corneal epithelium and endothelium [PDF]
Christopher J. Handley+1 more
openalex +1 more source
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins+2 more
wiley +1 more source
Purpose: To determine whether the mouse corneal endothelium enters endothelial to mesenchymal transition (EndoMT) following surgical injury in vivo. Methods: The corneal endothelium in anesthetized mice was surgically injured in vivo under direct ...
JeongGoo Lee, Eric Jung, Martin Heur
doaj