Results 41 to 50 of about 215,964 (304)

Triglyceride-rich lipoproteins prevent septic death in rats. [PDF]

, 1995
Triglyceride-rich lipoproteins bind and inactive bacterial endotoxin in vitro and prevent death when given before a lethal dose of endotoxin in animals.
Calhoun, MC, Feingold, KR, Grunfeld, C, Kane, JP, Kumwenda, ZL, Rapp, JH, Read, TE   +6 more
core  

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs [PDF]

, 2017
Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists.
A Clauss, A Gatt, A Tripodi, A Zambruni, AF Riddell, AO Spiel, B Agarwal, B Agarwal, B Agarwal, DJ Antoine, DJ Antoine, E Gehrie, EA Sankey, FB Mayr, GC Hugenholtz, H Schochl, HJ Tsai, J Vaquero, JG O’Grady, JH Griffin, KC Lee, KC Lee, L Rinaldi, LA Baker, M Habib, M Senzolo, M Yamaguchi, MJ McPhail, P Chowdary, R Jalan, R Kanel von, RT Stravitz, RT Stravitz, SJ Deventer van, SJ Munoz, SR Ostrowski, T Lisman, T Lisman, TE Warkentin, V Rewari   +39 more
core   +4 more sources

Mechanisms of endotoxin shock and endotoxin hypersensitivity

Immunobiology, 1993
Endotoxins (lipopolysaccharide, LPS) are biologically active substances present in Gram-negative bacteria. Injection of purified LPS into experimental animals leads to the development of many biological activities that can lead to shock with lethal outcome.
C, Galanos, M A, Freudenberg
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Highly Sensitive Electrochemical Endotoxin Sensor Based on Redox Cycling Using an Interdigitated Array Electrode Device

Micromachines, 2023
The Limulus amebocyte lysate (LAL) reaction-based assay, the most commonly used endotoxin detection method, requires a skilled technician. In this study, to develop an easy-to-use and highly sensitive endotoxin sensor, we created an electrochemical ...
Kentaro Ito, Kumi Y. Inoue, Takahiro Ito-Sasaki, Miho Ikegawa, Shinichiro Takano, Kosuke Ino, Hitoshi Shiku   +6 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Removal of Endotoxin from rAAV Samples Using a Simple Detergent-Based Protocol

Molecular Therapy: Methods & Clinical Development, 2019
Endotoxin is the most common contaminant found in protein samples. Even a small amount of endotoxin can induce strong allergic reaction and death of a host organism.
Liudmyla Kondratova, Oleksandr Kondratov, Ragy Ragheb, Sergei Zolotukhin   +3 more
doaj   +1 more source

Beta-glucan reflects liver injury after preservation and transplantation in dogs. [PDF]

, 1999
Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend
Azoulay D, Bion JF, Blanot S, Clavien PA, Goto M, Hamilton G, Hodes DS, Kambayashi J, Kikuchi M, Levin J, Miyata T, Ruiz-Herrera J., Shuji Matsura, Starzl TE, Steininger R, Tadashi Katsuramaki, Tomomi Suzuki,, , Tanaka S, The Iwanaga S., Todo S, Yokoyama I, Yoshioka T, Zhang GH, Zhang GH, Zhu Y   +23 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Testing the relationship between gut permeability, elevation of systemic lipopolysaccharides and chronic disease : A thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University, Manawatu, New Zealand [PDF]

, 2016
The aim of my thesis was to test whether an increase in the permeability of the gut is accompanied by an increase in the level of systemic lipopolysaccharides (LPS), also referred to as endotoxin.
Gnauck, Anne
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