Results 61 to 70 of about 223,059 (285)

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Endotoxin and CD14 in the progression of biliary atresia

Journal of Translational Medicine, 2010
Background Biliary atresia (BA) is a typical cholestatic neonatal disease, characterized by obliteration of intra- and/or extra-hepatic bile ducts. However, the mechanisms contributing to the pathogenesis of BA remain uncertain. Because of decreased bile
Chen Ching-Mei, Eng Hock-Liew, Chuang Jiin-Haur, Chou Ming-Huei, Wang Chiou-Huey, Chen Chao-Long, Lin Tsun-Mei   +6 more
doaj   +1 more source

An in vitro study on factors affecting endotoxin neutralization in human plasma using the Limulus amebocyte lysate test

Scientific Reports, 2021
Endotoxin neutralization, caused by plasma components, makes it difficult to detect endotoxins in human blood. In this study, we investigated which factors influence the recovery of endotoxins using limulus ameobocyte lysate (LAL)-based assays.
Stephan Harm, Claudia Schildböck, Karin Strobl, Jens Hartmann   +3 more
doaj   +1 more source

Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]

, 2006
Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core   +2 more sources

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6.

PLoS ONE, 2019
Endotoxin, a component of the outer membrane of Gram-negative bacteria, has been extensively studied as a stimulator of the innate immune response. However, the temporal aspects and exposure-response relationship of endotoxin and resulting cytokine ...
Anders Thorsted, Salim Bouchene, Eva Tano, Markus Castegren, Miklós Lipcsey, Jan Sjölin, Mats O Karlsson, Lena E Friberg, Elisabet I Nielsen   +8 more
doaj   +1 more source

Beta-glucan reflects liver injury after preservation and transplantation in dogs. [PDF]

, 1999
Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend
Azoulay D, Bion JF, Blanot S, Clavien PA, Goto M, Hamilton G, Hodes DS, Kambayashi J, Kikuchi M, Levin J, Miyata T, Ruiz-Herrera J., Shuji Matsura, Starzl TE, Steininger R, Tadashi Katsuramaki, Tomomi Suzuki,, , Tanaka S, The Iwanaga S., Todo S, Yokoyama I, Yoshioka T, Zhang GH, Zhang GH, Zhu Y   +23 more
core   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia

Nutrition & Metabolism, 2013
Background Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes.
Mani Venkatesh, Hollis James H, Gabler Nicholas K   +2 more
doaj   +1 more source

The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics [PDF]

, 2009
Short-term antibiotic treatment profoundly affects the intestinal microbiota, which may lead to sustained changes in microbiota composition. Probiotics may restore such a disturbance.
Jonkers, D., Koning, C.J., Pennings, H.J., Rombouts, F.M., Smidt, H., Stobberingh, E., Stockbrügger, R.W., Wouters, E.   +7 more
core   +3 more sources