Results 61 to 70 of about 59,484 (241)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Perfiles Latinoamericanos, 2003 La política comercial de Estados Unidos proporciona a los países la oportunidad de vincular los acuerdos comerciales con compromisos de cooperación dirigidos a ayudar a los países pobres a superar necesidades de desarrollo sustentable básicas, como el ...
John Audley
doaj
ReligionsThis paper shifts the research perspective from “Buddhist monasteries” to “monastic Buddhism,” using Nālandā Mahāvihāra as a micro-level case to illuminate the broader support mechanism of Indian Buddhist monasteries, with particular focus on the concept
Huiyuan Bian
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The Hadiths Mentioned about Entering Paradise Without Judgment are in The Nine Books Analytical Study [PDF]
مجلة جامعة الأنبار للعلوم الإسلاميةWhat exists in this world is not equal to anything that exists in Paradise، which is why achieving it is the goal of every believer. After the believer lives in this world according to what he followed of worship، good deeds، and faith in God and His ...
Dr. Abdul Jabbar Abdul Sattar Rokan -
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Professional training of teachers for work with gifted children in rural schools
Russian Journal of Education and PsychologyBackground. The author of the article made an attempt to consider the theoretical aspects of the basis of professional preparation of educators for working with gifted children on the example of rural schools of the Republic of Sakha (Yakutia).
Yulia T. Antonova
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
ḤUKMU AL-WAQF ‘ALĀ MARĀKIZ MU‘ĀLAJATI AL-MUDMINĪN WA TA’ḤĪLIHIM FĪ AL-FIQH AL-ISLĀMĪ
Jurnal Al-DusturThis research aims to identify the ruling on Waqf on Centers for the treatment and rehabilitation of addicts in Islamic jurisprudence, the research was based on the descriptive analytical approach and then the Fiqh study of the subject, and the research ...
Hamza Abed AlKarim Hammad
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source