Results 81 to 90 of about 497,164 (343)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Artificial Intelligence in Arabic-English Translation: Comparative Linguistic and Stylistic Analysis for Selected Qur’anic Verses

open access: yesمجلة النور للدراسات الانسانية
Artificial intelligence (AI), in recent years, has become a very real tool that can aid society in addressing many issues, including the challenges faced in the translation.
Ayad Enad Khalaf Ayad Enad Khalaf   +1 more
doaj   +1 more source

Lilly Endowment Annual Report 2015 [PDF]

open access: yes, 2016
During 2015, the Endowment paid grants totaling $435.5 million. Community development grants accounted for $200.4 million (46 percent), religion grants accounted for $124.1 million (29 percent) and education grants accounted for $111.0 million (25 ...

core  

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

open access: yeseLife, 2018
A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell ...
Lori L O'Brien   +12 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The First Principle of Supervision in Endowment - A Jurisprudential and Legal Analysis [PDF]

open access: yesپژوهش‌های فقهی مسائل مستحدثه
Supervision in endowments (waqf) is divided into two types: exploratory and advisory. The purpose of exploratory supervision is to become informed about matters related to the endowed property in endowments.
غلامرضا یزدانی   +2 more
doaj   +1 more source

Response Detection of Castrate-Resistant Prostate Cancer to Clinically Utilised and Novel Treatments by Monitoring Phospholipid Metabolism [PDF]

open access: yes, 2017
The authors gratefully acknowledge funding from Grampian NHS Endowment. The use of Professor Zanda’s and Jaspar’s NMR equipment and Russell Gray’s assistance are also gratefully acknowledged.Peer reviewedPublisher ...
Alzyoud, Kholoud S   +3 more
core   +2 more sources

The endowment effect, discounting and the environment

open access: yesJournal of Environmental Economics and Management, 2019
There is a considerable body of evidence showing that our preferences exhibit both reference dependence and loss aversion, a.k.a. the endowment effect.
Simon Dietz, F. Venmans
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

NPO FINANCIAL RESOURCE FORMATION MECHANISMS

open access: yesФинансы: теория и практика, 2017
Viewed as the center of economic and social innovations, the «third sector» of the economy occupies a substantial niche in the current all-round development of the country.The need of reforming the financial relations of nonprofit organizations has been ...
A. V. Grishchenko
doaj  

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