Results 1 to 10 of about 77,472 (115)

Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes [PDF]

Pharmaceutics, 2022
Lyophilization process design still relies mainly on empirical studies with high experimental loads. In the regulatory demanded Quality by Design approach, process modeling is a key aspect.
Alex Juckers, Petra Knerr, Frank Harms, Jochen Strube   +3 more
doaj   +4 more sources

Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer [PDF]

Animals
Due to late-stage diagnoses and limited treatment options, pancreatic cancer is predicted to be the second leading cause of cancer deaths by 2030. Many different murine models were developed over the past decades to test new therapies for this tumor ...
Jakob Brandstetter, Lisa Hoffmann, Ingo Koopmann, Tim Schreiber, Benjamin Schulz, Stephan Patrick Rosshart, Dietmar Zechner, Brigitte Vollmar, Simone Kumstel   +8 more
doaj   +2 more sources

Posterior endpoint determination of the lumbar pedicle central axis on the anterior–posterior fluoroscopic image for pedicle screw insertion [PDF]

Scientific Reports
The transpedicular procedure has been widely used in spinal surgery. The determination of the best entry point is the key to perform a successful transpedicular procedure.
Jun Zhang, Jiawei Xu, Chenyang Xu, Youzhuan Xie   +3 more
doaj   +2 more sources

Determination of quasi-primary odors by endpoint detection

Scientific Reports, 2021
It is known that there are no primary odors that can represent any other odors with their combination. Here, we propose an alternative approach: “quasi” primary odors.
Hanxiao Xu, Koki Kitai, Kosuke Minami, Makito Nakatsu, Genki Yoshikawa, Koji Tsuda, Kota Shiba, Ryo Tamura   +7 more
doaj   +1 more source

Determination of the immunoglobulin G precipitation end-point by an intelligent near-infrared spectroscopy system

Journal of Innovative Optical Health Sciences, 2021
Precipitation is a key manufacturing unit during the immunoglobulin G (IgG) production, which guarantees the quality of the final product. Ethanol is usually used to purify IgG during the precipitation process, so it is important to monitor the ethanol ...
Chen Yu, Shuang Quan, Cui Yang, Chengliang Zhang, Jiajin Fan, Lian Li, Hengchang Zang   +6 more
doaj   +1 more source

A Core Outcome Set for nutritional intervention studies in older adults with malnutrition and those at risk: a study protocol

BMC Geriatrics, 2023
Background Malnutrition (i.e., protein-energy malnutrition) in older adults has severe negative clinical consequences, emphasizing the need for effective treatments.
Marjolein Visser, Nuno Mendonça, Christina Avgerinou, Sibel Cavdar, Tommy Cederholm, Alfonso J. Cruz-Jentoft, Eva Kiesswetter, Hanna M. Siebentritt, Cornel Sieber, Gabriel Torbahn, Dorothee Volkert   +10 more
doaj   +1 more source

End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process

International Journal of Pharmaceutics: X, 2023
In this study, the torque profiles of heterogeneous granulation formulations with varying powder properties in terms of particle size, solubility, deformability, and wettability, were studied, and the feasibility of identifying the end-point of the ...
Ashley Dan, Haresh Vaswani, Alice Šimonová, Aleksandra Grząbka-Zasadzińska, Jingzhe Li, Koyel Sen, Shubhajit Paul, Yin-Chao Tseng, Rohit Ramachandran   +8 more
doaj   +1 more source

HTA und aktuelle Herausforderungen: Harmonisierung, Real World Data und Surrogatparameter

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2018
Health Technology Assessment is one of the standard instruments in support of the decision-making to define the public health services both internationally and in the German health care system.
Rüther, Alric, Herrmann, Kirsten H., Hebborn, Ansgar, Perleth, Matthias, Schwarzer, Ruth, Schürmann, Christoph, Sieben, Wiebke, Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm, Schramm, Wendelin   +11 more
doaj   +1 more source

Evaluation of Event-Free Survival Surrogating Overall Survival as the Endpoint in Neoadjuvant Clinical Trials of Gastroesophageal Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is one of the most common malignant cancers worldwide. The development of potential antitumor agents is being investigated and stimulates more clinical trials.
Hua Liu, Yakun Wang, Changsong Qi, Tong Xie, Zhi Peng, Jian Li, Lin Shen, Xiaotian Zhang   +7 more
doaj   +1 more source

Vertebral Heart Score: A Useful Parameter in Determination of Resuscitation Endpoint in Dogs with Hemorrhagic Shock [PDF]

Iranian Journal of Veterinary Medicine, 2019
BACKGROUND: GReliable prediction of patient response to fluid resuscitation is a crucial issue in the management of hemorrhagic shock. OBJECTIVES: This study was designed to investigate vertebral heart score (VHS) variation in fluid resuscitation of ...
Reza Azargoun, Reza Avizeh, Alireza Ghadiri, Hadi Imani Rastabi, Mahdi Pourmahdi   +4 more
doaj   +1 more source