Results 1 to 10 of about 73,823 (281)

Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes [PDF]

Pharmaceutics, 2022
Lyophilization process design still relies mainly on empirical studies with high experimental loads. In the regulatory demanded Quality by Design approach, process modeling is a key aspect.
Alex Juckers, Petra Knerr, Frank Harms, Jochen Strube   +3 more
doaj   +4 more sources

Determination of quasi-primary odors by endpoint detection [PDF]

Scientific Reports, 2021
It is known that there are no primary odors that can represent any other odors with their combination. Here, we propose an alternative approach: “quasi” primary odors.
Hanxiao Xu, Koki Kitai, Kosuke Minami, Makito Nakatsu, Genki Yoshikawa, Koji Tsuda, Kota Shiba, Ryo Tamura   +7 more
doaj   +4 more sources

Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer [PDF]

Animals
Due to late-stage diagnoses and limited treatment options, pancreatic cancer is predicted to be the second leading cause of cancer deaths by 2030. Many different murine models were developed over the past decades to test new therapies for this tumor ...
Jakob Brandstetter, Lisa Hoffmann, Ingo Koopmann, Tim Schreiber, Benjamin Schulz, Stephan Patrick Rosshart, Dietmar Zechner, Brigitte Vollmar, Simone Kumstel   +8 more
doaj   +4 more sources

Posterior endpoint determination of the lumbar pedicle central axis on the anterior–posterior fluoroscopic image for pedicle screw insertion [PDF]

Scientific Reports
The transpedicular procedure has been widely used in spinal surgery. The determination of the best entry point is the key to perform a successful transpedicular procedure.
Jun Zhang, Jiawei Xu, Chenyang Xu, Youzhuan Xie   +3 more
doaj   +2 more sources

Simple Modification of Karl-Fischer Titration Method for Determination of Water Content in Colored Samples [PDF]

Journal of Analytical Methods in Chemistry, 2012
The most commonly used technique for water content determination is Karl-Fischer titration with electrometric detection, requiring specialized equipment. When appropriate equipment is not available, the method can be performed through visual detection of
Eva Tavčar, Erika Turk, Samo Kreft
doaj   +2 more sources

Two detection methods for the endpoint of the prepared reaction of N-(oxidiethylene)-2 benzothiazolyl sulfonamide and its analysis

Materials Research Express, 2020
In this work, a detection method using pH and ORP for the endpoint determination of the prepared reaction of N-(oxidiethylene)-2-benzothiazolyl sulfonamide (NOBS) was reported, and the properties of NOBS samples were comprehensively investigated ...
Yidong Zhang, Yanjun Liu, Zhenqiu Li, Junmeng Zhao, Xilei Tong, Quan Wang, Huixiong Qin, Ruibin Qing   +7 more
doaj   +2 more sources

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues [PDF]

BMC Biotechnology, 2010
Background RNA extracted from formalin-fixed paraffin-embedded (FFPE) samples is chemically modified and degraded, which compromises its use in gene expression studies.
Dobrovic Alexander, Mikeska Thomas, Takano Elena A, Byrne David J, Fox Stephen B   +4 more
doaj   +2 more sources

A meta-analysis of GFR slope as a surrogate endpoint for kidney failure [PDF]

, 2023
Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a candidate surrogate endpoint for clinical trials of chronic kidney disease (CKD) progression. Analyses across a diverse spectrum of interventions and populations
Malfait, T, Chow, KM, Estacio, RO, Wied, S, Chaudhari, J, Perrone, RD, Yu, A, Greene, T, Rauen, T, Hannedouche, T, Raz, I, Lewis, JB, Hunsicker, LG, Keane, WF, Manno, C, Heerspink, HJL, Arroyo, D, Haynes, R, Maes, BD, Toto, RD, Schena, FP, Saddelli, M, Perkovic, V ; https://orcid.org/, Perna, A, Collier, W, Carrara, F, Jardine, M ; https://orcid.org/, Pozzi, C, Maschio, G, Blankestijn, PJ, Dwyer, J, Makino, H, Remuzzi, G, Barrett, B, Johnson, D, von Eynatten, M, Hanratty, R, Landray, M, Trujillo, H, de Jong, PE, Chapman, A, Locatelli, F, Verde, E, Floege, J, Miao, S, Ruggenenti, P, Neal, B ; https://orcid.org/, Appel, GB, Caravaca-Fontán, F, Li, PKT, Imai, E, Wetzels, JFM, Hou, FF, Seikrit, C, Haaland, B, Torres, V, Del Vecchio, L, Goicoechea, M, van Zuilen, A, Chalmers, J ; https://orcid.org/, Herrington, WG, Andrulli, S, Pohl, MA, Cavero, T, Brosnahan, G, Leung, CB, Vanacker, A, Chan, JCN, Wanner, C, Praga, M, Neuen, BL ; https://orcid.org/, Mahaffey, KW, Inker, LA, Woodward, M ; https://orcid.org/, Verdalles, U, Canetta, P, Badve, SV ; https://orcid.org/, Casartelli, D, Sevillano, A, Baigent, C, Szeto, CC, Kobayashi, F, Xie, D, Jafar, TH   +83 more
core   +3 more sources

Determination of the immunoglobulin G precipitation end-point by an intelligent near-infrared spectroscopy system

Journal of Innovative Optical Health Sciences, 2021
Precipitation is a key manufacturing unit during the immunoglobulin G (IgG) production, which guarantees the quality of the final product. Ethanol is usually used to purify IgG during the precipitation process, so it is important to monitor the ethanol ...
Chen Yu, Shuang Quan, Cui Yang, Chengliang Zhang, Jiajin Fan, Lian Li, Hengchang Zang   +6 more
doaj   +1 more source

Advanced Process Analytical Technology in Combination with Process Modeling for Endpoint and Model Parameter Determination in Lyophilization Process Design and Optimization [PDF]

, 2021
Lyophilization is widely used in the preservation of thermolabile products. The main shortcoming is the long processing time. Lyophilization processes are mostly based on a recipe that is not changed, but, with the Quality by Design (QbD) approach and ...
Alex Juckers, Jochen Strube, Petra Knerr, Knerr, Petra, Harms, Frank, Frank Harms, Juckers, Alex, Strube, Jochen   +7 more
core   +1 more source