The Impasse on Overall Survival in Oncology Reimbursement Decision-Making: How Can We Resolve This?
Michael Patrick Lux, 1 Oriana Ciani, 2 William CN Dunlop, 3 Andrea Ferris, 4 Michael Friedlander 5 1Department of Gynecology and Obstetrics, Frauenklinik St. Louise Paderborn, St. Josefs-Krankenhaus Salzkotten, Frauen- und Kinderklinik St.
Lux MP +4 more
doaj
Guideline Recommendation for Endpoints Used in Clinical Trials for Functional Dyspepsia
Functional dyspepsia is a disease, in which there is no organic lesion but chronic and repetitive postprandial fullness, early satiation, epigastric pain, and epigastric burning. Functional dyspepsia is not life-threatening but its symptoms are relapsing
Han Hee Lee +2 more
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Endpoints for Determining Mineral Element Requirements; An Introduction [PDF]
There are numerous measures of essential mineral element status, including growth rate, tissue and physiological fluid concentrations, enzyme concentrations and activities, chemical balance and mobilizable stores. For the adult human, blood and its specific nutrient concentrations provide a useful but frequently inadequate index.
openaire +2 more sources
Surrogate endpoint biomarkers for cervical cancer chemoprevention trials [PDF]
Cervical intraepithelia neoplasia (CIN) represents a spectrum of epithelial changes that provide an excellent model for developing chemopreventive interventions for cervical cancer.
Brenner, Dean E. +5 more
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Objective and perspective determine the choice of composite endpoint
The most important consideration in the choice of study design and endpoint is that these two features match and represent the objective and the perspective of the trial as closely as possible. The mechanism may also be helpful, but arguments based on the mechanism, structure or levels of the variables, or based on practical considerations, such as ...
Borm, G.F. +3 more
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Prediction Model of Phosphorus Content at the End Point of Electroslag Remelting Based on MI and XGBoost Algorithms [PDF]
This study proposes a phosphorus content prediction model for the endpoint of electroslag remelting (ESR) refining process based on Mutual Information (MI) method and XGBoost.
Liu Yuxiao, Dong Yanwu, Jiang Zhouhua, Chen Xi
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Chelatometrische Titration von komplexbildenden Azofarbstoffen mit CuII-, CoII- und NiII-Ionen
The complex formation of azo dyes with CuII-, CoII- or NiII-ions can be carried out as a titration, preferably with CuII and voltametric endpoint indication. It is also possible to determine the above ions with a suitable azo dye.
B. Bruttel, E. Ruhlmann, C. Wittwer
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Wet granulation in laboratory-scale high shear mixers: Effect of chopper presence, design and impeller speed [PDF]
The effect of the main means of agitation in a high shear mixer has been investigated in this study. Granulation runs have been performed on a fine cohesive microcrystalline cellulose powder (Avicel 105, d50 = 20 μm) often used as a pharmaceutical ...
Hemati, Mehrdji +5 more
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The anode furnace is a key piece of equipment in the copper smelting process and plays a vital role in producing high-quality copper. Accurately determining the endpoint during the anode furnace reduction process is critical to ensuring copper quality ...
Bi Zhao +4 more
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Semi-Correlations for Building Up a Simulation of Eye Irritation
The OECD recognizes that data on a compound’s ability to treat eye irritation are essential for the assessment of new compounds on the market. In silico models are frequently used to provide information when experimental data are lacking.
Andrey A. Toropov +3 more
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