Results 101 to 110 of about 1,860,209 (301)

Summary Report: Afghanistan Implementation Colloquium

, 2010
The report suggests that perceptions and lack of trust are key issues complicating governance reform in Afghanistan and the transfer of responsibilities for security and development from the international community to the Afghan government.
Liechtenstein Institute on Self-Determination
core   +1 more source

Endpoint estimates for Rubio de Francia operators

, 2019
The extrapolation theory of Rubio de Francia provides a tool to obtain Ap weighted estimates on Lp spaces for every 1
Domingo Salazar, Carlos, Carro Rossell, María Jesús   +1 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Sex determination in Aedes aegypti.

, 2011
We proposed an hypothetical model for sex determination in Aedes that is presented here. In this model we hypothesized the existence of two different upstream regulators that we named SR-M and SR-F (SR is for Splicing Regulator, not necessarily an SR ...
SALVEMINI, MARCO, D'AMATO, ROCCO, PETRELLA, VALERIA, SACCONE, GIUSEPPE, POLITO, CATELLO   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Toward a Sovereign Afghanistan

, 2011
Focusing on four key issue areas relevant to the immediate and near future of Afghanistan including governance and economy, identity, reconciliation and reintegration, and the region and macro region, the Liechtenstein Institute on Self-Determination ...
Liechtenstein Institute on Self-Determination
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Grand Strategy and Self-Determination

, 2015
This report is the chair's summary from the colloquium, "Grand Strategy and Self-Determination," sponsored by the Liechtenstein Institute on Self-Determination at Princeton University, November 19-20, 2014.The notions of “grand strategy” and “self ...
Liechtenstein Institute on Self-Determination
core  

Overview of in-process parameters at pilot and production scale that are useful for monitoring primary drying and primary drying endpoint determination.

, 2016
Overview of in-process parameters at pilot and production scale that are useful for monitoring primary drying and primary drying endpoint determination.
K. Reubsaet (3177963), G. Kersten (3177942), J.-P. Amorij (3177954), R. ten Have (3177939), P. van Herpen (3177936)   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source