Results 111 to 120 of about 1,860,209 (301)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

RADAR-base/radar-helm-charts: radar-push-endpoint-0.2.4

<p>A Helm chart for RADAR-base Push Endpoint. REST Gateway to Kafka, for incoming data from Push or Subscription based WEB APIs. It performs authentication, authorization and content validation.
Joris Borgdorff, Pauline Conde, Heet Sankesara, Yatharth Ranjan, Keyvan, Julien D., Pim van Nierop, Bastiaan   +7 more
core   +1 more source

Example of endpoint calibration.

, 2018
(A) Visualization of calibration process, showing five samples measured with varied rotations about the selected endpoint. Black spheres indicate the estimated endpoint location for each sample, and blue lines connect the estimated endpoint to the ...
Christopher C. Cline (6000533), Bin He (75597), Christopher Coogan (5705153)   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Toward a mRNAseq analysis to explore the transcriptome landscapes of Ceratitis capitata sexed early embryos.

, 2011
Sex determination study of Medfly embryos using ...
SALVEMINI, MARCO, PETRELLA, VALERIA, SACCONE, GIUSEPPE, PANE, ATTILIO, Nagaraju J, D’Amato R, POLITO, CATELLO   +6 more
core  

RADAR-base/radar-helm-charts: radar-push-endpoint-0.2.3

<p>A Helm chart for RADAR-base Push Endpoint. REST Gateway to Kafka, for incoming data from Push or Subscription based WEB APIs. It performs authentication, authorization and content validation.
Joris Borgdorff, Pauline Conde, Heet Sankesara, Yatharth Ranjan, Keyvan, Julien D., Bastiaan   +6 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Quantitative determination of embolization endpoints based on local arterial pressure

Bioengineering & Translational Medicine
Abstract This study aims to optimize the embolization endpoint to improve therapeutic outcomes in interventional procedures and minimize the risk of ectopic embolism caused by excessive embolic agent injection. Hemodynamic changes during embolization were simulated by modeling the terminal resistance vessels as a porous medium.
Dongcheng Ren, Xingyuan Li, Shijie Guo, Yuchi Tian, Baolei Guo, Bo Zhou   +5 more
openaire   +3 more sources

Correspondence to letter to the editor on “Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial” [PDF]

Clinical and Molecular Hepatology
Woo Hyun Paik, Heon Se Jeong, Do Hyun Park   +2 more
doaj   +1 more source

Male-specific phophorylated SR splicing proteins in adult flies of the mediterannean fruitfly Ceratitis capitata.

, 2013
Sex determination study on male-specific phophorylated SR splicing proteins in adult flies of the mediterannean fruitfly Ceratitis ...
SALVEMINI, MARCO, Di Natale M, SACCONE, GIUSEPPE, Perri M, Zhang H, Louis C, Lancieri M, POLITO, CATELLO   +7 more
core