Results 201 to 210 of about 80,523 (260)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Genomics May Be the Key to Understanding Endurance Training Pillars. [PDF]

Genes (Basel)
Bottura RM, Dentillo DB.
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Effects of Low-Intensity Endurance Training on Aerobic Fitness and Risk Factors of Cardiometabolic Health in Working-Age Adults: A Systematic Review and Meta-Analysis. [PDF]

Scand J Med Sci Sports
Nuuttila OP, Matomäki P, Raitanen J, Sievänen H, Vasankari T.   +4 more
europepmc   +1 more source

Stage-Dependent Brain Plasticity Induced by Long-Term Endurance Training: A Longitudinal Neuroimaging Study. [PDF]

Life (Basel)
Zhang K, Yan Q, Jiang L, Liang D, Cao C, Zhang D.   +5 more
europepmc   +1 more source

Endurance training mitigates obesity-induced hippocampal impairment by enhancing neurotrophin signalling, synaptic plasticity, and cellular responses in a female rat model. [PDF]

IBRO Neurosci Rep
Kuruc T, Kuchárová K, Kisucká A, Ileninová M, Ihnátová L, Bimbová KK, Magurová M, Gálik J, Lukáčová N.   +8 more
europepmc   +1 more source

Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner. [PDF]

J Physiol
Lam B, Gulri M, Akhtar S, Lemieux P, Tawadrous M, Murugathasan M, Abdul-Sater AA, Roudier E.   +7 more
europepmc   +1 more source

Molecular Network Analysis and Effector Gene Prioritization of Endurance-Training-Influenced Modulation of Cardiac Aging. [PDF]

Genes (Basel)
Wang M, Azhati S, Chen H, Zhang Y, Shi L.   +4 more
europepmc   +1 more source

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Altitude and endurance training

Journal of Sports Sciences, 2004
The benefits of living and training at altitude (HiHi) for an improved altitude performance of athletes are clear, but controlled studies for an improved sea-level performance are controversial. The reasons for not having a positive effect of HiHi include: (1) the acclimatization effect may have been insufficient for elite athletes to stimulate an ...
Heikki K, Rusko, Heikki O, Tikkanen, Juha E, Peltonen   +2 more
openaire   +2 more sources

Strength Training in Endurance Runners

International Journal of Sports Medicine, 2010
This study examined effects of periodized maximal versus explosive strength training and reduced strength training, combined with endurance training, on neuromuscular and endurance performance in recreational endurance runners. Subjects first completed 6 weeks of preparatory strength training.
Ari Nummela, Keijo Häkkinen, W Kraemer   +2 more
exaly   +3 more sources