Results 51 to 60 of about 48,219 (257)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring the effects of inserting heteroatoms (N, O, S) into 9-heterocyclo[3.3.1]nonane frameworks on the properties of their energetic derivatives

Energetic Materials Frontiers
Bicyclo[3.3.1]nonane scaffold is a privileged ring system frequently encountered in a variety of cage-like compounds. Exploring the synthesis of bicyclo[3.3.1]nonane is of great significance for the design and application of cage-like energetic compounds.
Yun-zhi Liu, Yuan Gao, Zhen-xin Yi, Gui-xiang Wang, Ze-quan Zhao, Tian-jiao Hou, Yu Zhang, Jun Luo   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Adsorption and Removal of 2,4,6-Trinitrotoluene by a Glycoluril-Derived Molecular-Clip-Based Supramolecular Organic Framework

Molecules
A glycoluril-derived molecular-clip-based supramolecular organic framework (clip-SOF) with intrinsic porosity was prepared. The clip-SOF was used for the adsorption and removal of 2,4,6-trinitrotoluene (TNT) driven by noncovalent interactions.
Yuezhou Liu, Shu Zeng, Xiaokai He, Yang Wu, Yang Liu, Yinglei Wang   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Correlation between the self-sustaining ignition ability and the impact sensitivity of energetic materials

Energetic Materials Frontiers, 2020
Sensitivity is one of the most important characteristics of energetic materials (EMs), and uncovering the sensitivity mechanism is still a challenge. In this work, we find that the self-sustaining ignition ability is a predominant factor governing the ...
Xiaoxue Xiong, Xudong He, Ying Xiong, Xianggui Xue, Haijun Yang, Chaoyang Zhang   +5 more
doaj   +1 more source

DESIGN OF SOME ENERGETIC COMPOUNDS

FUDMA JOURNAL OF SCIENCES
Due to the increasing production of modern explosive-resistant vehicles, materials, and equipment, the calls for improved energetic materials (EMs) with a more destructive energetic capability and high thermal stability for engineering and warfare have received tremendous attention from researchers. Weka version 3.8.5 machine learning software has been
Yakasai Jamila Bashir, Fyafa Hannah Habila, Umar Abdulmumuni, Abdulfatai Usman   +3 more
openaire   +1 more source