Results 41 to 50 of about 496,175 (298)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Pyrolysis mechanism and evolved gas analysis of a promising energetic carbamate-functionalized microcrystalline cellulose nitrate

open access: yesFirePhysChem
The present study aims to elucidate the decomposition mechanism and gas evolution characteristics of a promising energy-rich carbamated microcrystalline cellulose nitrate (M3CN).
Hani Boukeciat   +7 more
doaj   +1 more source

Prediction and Construction of Energetic Materials Based on Machine Learning Methods

open access: yesMolecules, 2022
Energetic materials (EMs) are the core materials of weapons and equipment. Achieving precise molecular design and efficient green synthesis of EMs has long been one of the primary concerns of researchers around the world.
Xiaowei Zang   +7 more
doaj   +1 more source

SELECTION OF LIPIDS FROM BLUE-GREEN ALGAE [PDF]

open access: yes, 2018
Annually Ukraine consumes about 200 million tons of fuel oil equivalent, however, the mining from country’s natural resources is only 80 million tons.
Chelnakova, Olena   +3 more
core  

Selective Laser Sintering of Passive Dynamic Ankle-Foot Orthoses [PDF]

open access: yes, 2006
Passive dynamic ankle-foot orthoses (AFO’s) are used to improve gait performance in those with various neuromuscular disorders. An important design characteristic of passive dynamic AFOs is the storage and release of elastic energy within its structure
Crawford, Richard H.   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Development of an Integrated System of sEMG Signal Acquisition, Processing, and Analysis with AI Techniques

open access: yesSignals
The development of robust circuit structures remains a pivotal milestone in electronic device research. This article proposes an integrated hardware–software system designed for the acquisition, processing, and analysis of surface electromyographic (sEMG)
Filippo Laganà   +6 more
doaj   +1 more source

Study on Shock Initiation Randomness of Energetic Materials on a Macroscopic Scale

open access: yesApplied Sciences, 2023
The shock initiation randomness problem of energetic materials (SIREM) is an important problem in the research field of energetic material safety.
Lan Liu   +5 more
doaj   +1 more source

Electron-Hole Liquids in Transition Metal Oxide Heterostructures

open access: yes, 2010
Appropriately designed transition metal oxide heterostructures involving small band gap Mott insulators are argued to support spatially separated electron and hole gasses at equilibrium. Spatial separations and carrier densities favoring the formation of
Millis, Andrew J., Schlom, Darrell G.
core   +1 more source

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