Results 41 to 50 of about 447,247 (352)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Impact of temperature and humidity on the thermal decomposition behavior and the ignition characteristics of Si-based pyrotechnic delay composition

FirePhysChem
This study focuses on analyzing the degradation, ignition, and combustion behavior of a silicon (Si)-based pyrotechnic delay mixture. A comparative analysis is conducted between a fresh sample and one exposed to accelerated aging conditions at a constant
Slimane Bekhouche, Amir Abdelaziz, Ahmed Fouzi Tarchoun, Widad Benchaa, Salim Chelouche, Fateh Chalgoum, Mohammed Jouini, Weiqiang Pang, Djalal Trache   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Energetic Materials at High Compression: First-Principles Density Functional Theory and Reactive Force Field Studies [PDF]

, 2006
We report the results of a comparative study of pentaerythritol tetranitrate (PETN) at high compression using classical reactive interatomic potential ReaxFF and first-principles density functional theory (DFT).
Conroy, M., Goddard, W. A., III, Oleynik, I. I., van Duin, A. C. T., White, C. T., Zhang, L., Zybin, S. V.   +6 more
core   +1 more source

Thermal decomposition behavior of ammonium perchlorate/nitrated microcrystalline cellulose carbamate/diethylene glycol dinitrate energetic composite

FirePhysChem
This study reports the successful preparation of an energetic composite consisting of ammonium perchlorate (AP), nitrated microcrystalline cellulose carbamate (M3CN), and diethylene glycol dinitrate (DEGDN).
Hani Boukeciat, Ahmed Fouzi Tarchoun, Amir Abdelaziz, Chemseddine Boustila, Aymen Bouhantala, Thomas M. Klapötke, Djalal Trache   +6 more
doaj   +1 more source

Effect of micro- and nano-CuO on the thermal decomposition kinetics of high-performance aluminized composite solid propellants containing complex metal hydrides

FirePhysChem, 2022
In the present work, an attempt has been made to unveil the effect of micro- and nano-particles of copper oxide (µCuO and nCuO) on the thermal decomposition of composite solid propellants (CSPs) based on ammonium perchlorate, hydroxyl terminated ...
Fateh Chalghoum, Djalal Trache, Mokhtar Benziane, Abdenacer Benhammada   +3 more
doaj   +1 more source