Results 51 to 60 of about 29,430 (259)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Sawtooth Stabilization by Energetic Trapped Particles [PDF]

Physical Review Letters, 1988
Recent experiments involving high-power radio-frequency heating of a tokamak plasma show strong suppression of the sawtooth oscillation. A high-energy trapped-particle population is shown to have a strong stabilizing effect on the internal resistive kink mode. Numerical calculations are in reasonable agreement with experment.
, White, , Rutherford, , Colestock, , Bussac   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Energetic particle instabilities in fusion plasmas [PDF]

Nuclear Fusion, 2013
37 pages, 20 ...
Sharapov, S. E., Alper, B., Berk, H. L., Borba, D. N., Breizman, B. N., Challis, C. D., Classen, I. G. J., Edlund, E. M., Eriksson, J., Fasoli, A., Fredrickson, E. D., Fu, G. Y., Garcia Munoz, M., Gassner, T., Ghantous, K., Goloborodko, V., Gorelenkov, N. N., Gryaznevich, M. P., Hacquin, S., Heidbrink, W. W., Hellesen, C., Kiptily, V. G., Kramer, G. J., Lauber, P., Lilley, M. K., Lisak, M., Nabais, F., Nazikian, R., Nyqvist, R., Osakabe, M., Perez von Thun, C., Pinches, S. D., Podesta, M., Porkolab, M., Shinohara, K., Schoepf, K., Todo, Y., Toi, K., Van Zeeland, M. A., Voitsekhovich, I., White, R. B., Yavorskij, V., Itpa, EP TG, Abel, I., Afanesyev, V., Aftanas, M., Agarici, G., Aggarwal, K. M., Aho Mantila, L., Ahonen, E., Aints, M., Airila, M., Akers, R., Alarcon, T., Albanese, R., Alexeev, A., Alfier, A., Allan, P., Almaviva, S., Alonso, A., Altmann, H., Alves, D., Ambrosino, G., Amosov, V., Andersson, F., Anderssonsund ́en, E., Andreev, V., Andrew, Y., Angelone, M., Anghel, M., Anghel, A., Angioni, C., Apruzzese, G., Arcis, N., Arena, P., Argouarch, A., Ariola, M., Armitano, A., Armstrong, R., Arnoux, G., Arshad, S., Artaserse, G., Artaud, J. F., Ash, A., Asp, E., Asunta, O., Atanasiu, C. V., Atkins, G., Avotina, L., Axton, M. D., Ayres, C., Baciero, A., Bailescu, V., Baiocchi, B., Baker, R. A., Balboa, I., Balden, M., Balorin N. Balshaw, C. Balorin N. Balshaw, Banks, J. W., Baranov, Y. F., Barbier, D., Barlow, I. L., Barnard, M. A., Barnsley, R., Barrena, L., Barrera, L., Baruzzo, M., Basiuk, V., Bateman, G., Batistoni, P., Baumgarten, N., Baylor, L., Bazylev, B., Beaumont, P. S., Beausang, K., B ́ecoulet, M., Bekris, N., Beldishevski, M., Bell, A. C., Belli, F., Bellinger, M., Bellizio, T., Belo, P. S. A., Belonohy, E., Bennett, P. E., Benterman, N. A., Berger By, G., Bergsåker, H., Berk, H., Bernardo, J., Bernert, M., Bertrand, B., Beurskens, M. N. A., Bieg, B., Bienkowska, B., Biewer, T. M., Bigi, M., B ́ılkov ́a, P., Bin, W., Bird, J., Bizarro, J., Bj ̈orkas, C., Blackman, T. R., Blanchard, P., Blanco, E., Blum, J., Bobkov, V., Boboc, A., Boilson, D., Bolshakova, I., Bolzonella, T., Boncagni, L., Bonheure, G., Bonnin, X., Borba, D., Borthwick, A., Botrugno, A., Boulbe, C., Bouquey, F., Bourdelle, C., Bovert, K. V., Bowden, M., Boyce, T., Boyer, H. J., Bozhenkov, A., Brade, R. J., Bradshaw, J. M. A., Braet, J., Braic, V., Braithwaite, G. C., Brault, C., Breizman, B., Bremond, S., Brennan, P. D., Brett, A., Breue, J., Brezinsek, S., Bright, M. D. J., Briscoe, F., Brix, M., Brombin, M., Brown, B. C., Brown, D. P. D., Brzozowski, J., Bucalossi, J., Buckley, M. A., Budd, T., Budny, R. V., Bunting, P., Buratti, P., Burcea, G., Burckhart, A., Butcher, P. R., Buttery, R. J., Cahyna, P., Calabr`o, G., Callaghan, C. P., Caminade, J. P., Camp, P. G., Campling, D. C., Gorelenkov, N., Kramer, G., Romanelli, F.   +202 more
openaire   +9 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Oil-in-water nanoemulsion adhesive system: Preparation by ultrasonic homogenization and its application in 3D direct writing composite energetic materials

Journal of Materials Research and Technology
Stable and low-particle size nanoemulsions were prepared using ultrasound homogenization. The conditions for preparing low-viscosity nanoemulsions were optimized using Response Surface Methodology (RSM) experimental design.
Kai Han, Shijiao Li, Chenyang Li, Ming Li, XiaWei Zhang, Zhanxiong Xie, Yi Liu, Chongwei An, Jingyu Wang   +8 more
doaj   +1 more source

Energetic particle dynamics in Mercury's magnetosphere [PDF]

Journal of Geophysical Research: Space Physics, 2013
We investigate the drift paths of energetic particles in Mercury's magnetosphere by tracing their motion through a model magnetic field. Test particle simulations solving the full Lorentz force show a quasi‐trapped energetic particle population that gradient and curvature drift around the planet via “Shabansky” orbits, passing though high latitudes in ...
B. M. Walsh, A. S. Ryou, D. G. Sibeck, I. I. Alexeev   +3 more
openaire   +1 more source

Proton Acceleration in Low-β Magnetic Reconnection with Energetic Particle Feedback

The Astrophysical Journal
Magnetic reconnection regions in space and astrophysics are known as active particle acceleration sites. There is ample evidence showing that energetic particles can take a substantial amount of converted energy during magnetic reconnection.
Jeongbhin Seo, Fan Guo, Xiaocan Li, Hui Li   +3 more
doaj   +1 more source

Energetic particle-mediated interplanetary shocks observed by Solar Orbiter

Astronomy & Astrophysics
Context. In collisionless shocks, energetic particles can carry enough pressure to modify the upstream plasma and the shock structure itself. This represents a regime that is often invoked in theories of cosmic-ray acceleration, but rarely observed in ...
Trotta D., Lario D., Reville B., Raptis S., Pezzi O., Hietala H., Mostafavi P., Giacalone J., Wimmer-Schweingruber R. F., Kuehl P., Kollhoff A., Turner D., Burgess D.   +12 more
doaj   +1 more source