Results 71 to 80 of about 517,027 (264)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Optimizing energy absorption and peak force in metal/glass fiber sandwich panels with trapezoidal cores

Scientific Reports
Sandwich panels with trapezoidal metal/glass fiber cores are increasingly popular due to their lightweight and energy-absorption properties. This study employs response surface methodology (RSM) and Box-Behnken design to investigate the effects of core ...
Mojtaba Lashgaroo, Ali Dadrasi, Vali Parvaneh, Hossein Taghipoor   +3 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Design Method of Carbody Front-end Energy-absorption Device for High-speed Trains

Chengshi guidao jiaotong yanjiu
ObjectiveTo optimize the passive safety protection performance of high-speed trains, it is necessary to design a carbody front-end energy-absorption device suitable for high-speed trains, so as to reduce the carbody deformation during collisions and ...
Shihong JIANG, Chengqiang WANG, Dongwei XIA, Hui JIN, Peng XU   +4 more
doaj   +1 more source

Perceived Impacts and Predictors of Cannabis Products used by Rheumatology Patients in Alberta: A Multivariable Analysis of Cross‐sectional Survey Data

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among rheumatology patients, and their associations with patient factors, patient reported perceived side effects and positive impacts. Methods An online survey (delivered from March to November 2022) was distributed by Alberta Health Services to ...
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Synergistic enhancement of load-bearing and energy-absorbing performance in additively manufactured lattice structures through modifications to conventional unit cells

Defence Technology
The unit cell configuration of lattice structures critically influences their load-bearing and energy absorption performance. In this study, three novel lattice structures were developed by modifying the conventional FBCCZ unit cell through reversing ...
Yi Ren, Yu Nie, Bowen Xue, Yucheng Zhao, Lulu Liu, Chao Lou, Yongxun Li, Wei Chen   +7 more
doaj   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Thermoreflectance Detection of Point Defects Resulting from Focused Ion Beam Milling

Advanced Engineering Materials, Volume 28, Issue 11, 3 June 2026.
Focused ion beam (FIB) milling is a common tool for nanoscale material processing, however irradiation damage, redeposition, and contamination can occur. We use several characterization tools to show FIB‐induced effects beyond 1 mm from the milled area.
Thomas W. Pfeifer, Eric R. Hoglund, Anton V. Ievlev, Patrick E. Hopkins   +3 more
wiley   +1 more source

STUDY ON ENERGY ABSORPTION CHARACTERISTIC OF SINUSOIDAL BELLOWS FILLED EMULSION ABSORBER

Jixie qiangdu
The pre⁃folded energy absorber is the only energy absorber structure used in rock burst mine at present.It has excellent energy absorption characteristics,but there are some problems in the buckling deformation process such as large load fluctuation and ...
ZHANG JianZhuo, ZHANG WanJiu, PAN YiShan, GUO Hao, WANG ShuWen   +4 more
doaj  

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source