Results 91 to 100 of about 2,751,201 (292)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Beyond leptin: emerging candidates for the integration of metabolic and reproductive function during negative energy balance

Frontiers in Endocrinology, 2011
Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance.
Cadence eTrue, Kevin eGrove, M Susan eSmith   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

UNLOCKING THE SECRETS OF PUBERTY ONSET: IS HYPOTHALAMIC LIPID-SENSING A KEY METABOLIC REGULATOR?

IBRO Neuroscience Reports, 2023
Elvira Rodríguez Vázquez, Álvaro Aranda Torrecillas, Cecilia Perdices López, Francisco Ruiz Pino, Ana Rodríguez Sánchez, Francisco Gaytán Luna, Juan Castellano Rodríguez, Manuel Tena Sempere   +7 more
doaj   +1 more source

Milk Metabolomics Data Reveal the Energy Balance of Individual Dairy Cows in Early Lactation

Scientific Reports, 2018
In early lactation, dairy cows typically have a negative energy balance which has been related to metabolic disorders, compromised health and fertility, and reduced productive lifespan.
Wei Xu, Jacques Vervoort, Edoardo Saccenti, Renny van Hoeij, Bas Kemp, Ariette van Knegsel   +5 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A subsynoptic-scale kinetic energy study of the Red River Valley tornado outbreak (AVE-SESAME 1) [PDF]

The subsynoptis-scale kinetic energy balance during the Red River Valley tornado outbreak is presented in order to diagnose storm environment interactions.
Fuelberg, H. E., Jedlovec, G. J.
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Evolution of plasma turbulence excited with particle beams

, 2012
Particles ejected from the Sun that stream through the surrounding plasma of the solar wind are causing instabilities. These generate wavemodes in a certain frequency range especially within shock regions, where particles are accelerated. The aim of this
Bavassano, Bell, Bershadskii, Bigot, Bruno, Chen, Drury, Elsässer, F. Spanier, Forbes, Forbush, Galinsky, Goldreich, Goldreich, Hollweg, Iroshnikov, Jin, Kahler, Kolmogorov, Kraichnan, Landi, Lee, Lithwick, Maron, Mininni, Ng, Orszag, Perez, Reames, S. Lange, Schlickeiser, Sridhar, Telloni, Tu, Vainio, Vainio, Vainio, Vainio, Vainio   +38 more
core   +1 more source