Results 151 to 160 of about 2,199,245 (317)

Conceptual market potential framework of high temperature aquifer thermal energy storage - A case study in the Netherlands

, 2018
High temperature aquifer thermal energy storage (HT-ATES) can contribute to the integration of renewable energy sources in the energy system, the replacement of fossil fuel-based heat supply and the utilization of surplus heat from industrial sources ...
Koornneef, Joris, Energy System Analysis, Energy and Resources, Wesselink, Maxim, van den Broek, Machteld, Liu, Wen   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Theoretical investigation of cycling stability in TiS2 anode for zinc-ion rechargeable batteries

JPhys Materials
To advance the development of aqueous zinc-ion batteries (ZIBs), which are considered a promising alternative for sustainable energy storage, it is a crucial step to explore zinc-free metal anodes to prevent zinc-dendrite formation.
Chayanon Atthapak, Natthapong Jampaiboon, Wiwittawin Sukmas, Björn Alling, Thiti Bovornratanaraks, Annop Ektarawong   +5 more
doaj   +1 more source

Model Design and Study of a U-Channel Photonic Crystal Fib Optic Sensor for Measuring Glucose Concentration in Blood

Sensors
This research introduces a biosensor utilizing surface plasmon resonance in a photonic crystal fiber (PCF) configuration. PCF uses fused silica as the base material, with a layer of gold placed over the U-channels in the cross-section of the fiber to ...
Lei Zhao, Hua Yang, Tangyou Sun, Qianju Song, Zao Yi, Yougen Yi   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessment of the Potential of Commercial Buildings for Energy Management in Energy Performance Contracts

Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.The Energy Performance Building Directive encourages Member States to establish clear long-term renovation strategies, highlighting the value of energy ...
de Agustín, Pablo, Garay-Martinez, Roberto, Garrido-Marijuan, Antonio, Eguiarte, Olaia   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

GASCAP: Accelerating Adsorption Evaluation Using Graph Voronoi Diagram and Machine Learning Method

Materials Genome Engineering Advances
Adsorption on a solid surface is a significant chemical process in the fields of gas sensors, solid catalysts, hydrogen storage materials, and ion batteries.
Wencai Yi, Jiping Xiong, Xingang Jiang, Yuqiu Zhang, Chaozheng He, Xiaobing Liu   +5 more
doaj   +1 more source

Design of a Photonic Crystal Fiber Optic Magnetic Field Sensor Based on Surface Plasmon Resonance

Sensors
To enhance the sensing performance of fiber-optic magnetic field sensors, we explored the design, optimization, and application prospects of a D-type fiber-optic magnetic field sensor.
Yuxuan Yi, Hua Yang, Tangyou Sun, Zao Yi, Zigang Zhou, Chao Liu, Yougen Yi   +6 more
doaj   +1 more source