Results 131 to 140 of about 2,199,245 (317)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Coupling night ventilative and active cooling to reduce energy use in supermarkets with high refrigeration loads [PDF]

, 2017
Night ventilation is used extensively as a low energy strategy to cool buildings in climates where night temperatures are suitable. It can be used for spaces utilising natural or mechanical ventilation systems as well as active refrigerant cooling.
Kolokotroni, M, Mylona, Z, Maria Kolokotroni, Tassou, S, Tassou, SA, Zoi Mylona, Savvas A. Tassou   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Exploring phonon mediated superconductivity of $$\hbox {LiB}_{{2}} \hbox {N}_{{2}}$$ and $$\hbox {LiC}_{{2}} \hbox {N}_{{2}}$$ under high pressure insight from first-principles calculations

Scientific Reports
Investigating novel materials under high pressure presents a challenge in condensed matter physics. In this study, we examine $$\hbox {LiB}_{{2}} \hbox {N}_{{2}}$$ and $$\hbox {LiC}_{{2}} \hbox {N}_{{2}}$$ , materials identified through an evolutionary ...
Prutthipong Tsuppayakorn-aek, Thiti Bovornratanaraks, Komsilp Kotmool   +2 more
doaj   +1 more source

The Numerical Simulation of the Transient Plane Heat Source Method to Measure the Thermophysical Properties of Materials

Applied Sciences
The transient plane heat source method (TPS), also known as the hot disc method, is an experimental method for determining the thermal transport properties of materials. The method’s main element is a sensor made of a nickel metal strip in the shape of a
Jianyuan Sun, Siwen Zhang, Pengcheng Shi, Zao Yi, Yougen Yi, Qingdong Zeng   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The National Interim Energy Consumption Survey (NIECS) data base.

, 1982
The purpose of this report is to evaluate the 1978-79 National Interim Energy Consumption Survey (NIECS) data base in terms of its usefulness for estimating residential energy demand models based on household appliance choice and utilization decisions ...
McFadden, Daniel, Cowing, Thomas G., Dubin, Jeffrey A.   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Estimating Harvestable Energy in Time-Varying Indoor Light Conditions

, 2020
Ambient light energy harvesting is a cost-effective and mature approach for supplying low-power sensor systems with power in many indoor applications.
Bader, Sebastian,, Ma, Xinyu,, Oelmann, Bengt,   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source