Results 141 to 150 of about 6,253,661 (292)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Theoretical investigation of cycling stability in TiS2 anode for zinc-ion rechargeable batteries

JPhys Materials
To advance the development of aqueous zinc-ion batteries (ZIBs), which are considered a promising alternative for sustainable energy storage, it is a crucial step to explore zinc-free metal anodes to prevent zinc-dendrite formation.
Chayanon Atthapak, Natthapong Jampaiboon, Wiwittawin Sukmas, Björn Alling, Thiti Bovornratanaraks, Annop Ektarawong   +5 more
doaj   +1 more source

Model Design and Study of a U-Channel Photonic Crystal Fib Optic Sensor for Measuring Glucose Concentration in Blood

Sensors
This research introduces a biosensor utilizing surface plasmon resonance in a photonic crystal fiber (PCF) configuration. PCF uses fused silica as the base material, with a layer of gold placed over the U-channels in the cross-section of the fiber to ...
Lei Zhao, Hua Yang, Tangyou Sun, Qianju Song, Zao Yi, Yougen Yi   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

GASCAP: Accelerating Adsorption Evaluation Using Graph Voronoi Diagram and Machine Learning Method

Materials Genome Engineering Advances
Adsorption on a solid surface is a significant chemical process in the fields of gas sensors, solid catalysts, hydrogen storage materials, and ion batteries.
Wencai Yi, Jiping Xiong, Xingang Jiang, Yuqiu Zhang, Chaozheng He, Xiaobing Liu   +5 more
doaj   +1 more source

Design of a Photonic Crystal Fiber Optic Magnetic Field Sensor Based on Surface Plasmon Resonance

Sensors
To enhance the sensing performance of fiber-optic magnetic field sensors, we explored the design, optimization, and application prospects of a D-type fiber-optic magnetic field sensor.
Yuxuan Yi, Hua Yang, Tangyou Sun, Zao Yi, Zigang Zhou, Chao Liu, Yougen Yi   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Enhancing the Overall Performance of Perovskite Solar Cells with a Nano-Pyramid Anti-Reflective Layer

Photonics
Perovskite solar cells (PSCs) still suffer from varying degrees of optical and electrical losses. To enhance the light decoupling and capture ability of Planar PSCs, an ultra-thin PSC structure with an Al2O3 pyramid anti-reflection layer (Al2O3 PARL) is ...
Li Liu, Wenfeng Liu, Wenfeng Fu, Zao Yi, Yougen Yi, Jianguo Zhang, Chaojun Tang, Tangyou Sun, Qingdong Zeng, Pinghui Wu   +9 more
doaj   +1 more source