Results 71 to 80 of about 1,377,021 (288)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular clustering unlocks high-performance hydrovoltaics across temperatures from −35 °C to 80 °C
Nature CommunicationsHydrovoltaic technologies face challenges of low conversion efficiency and narrow operational temperature ranges, limiting their practical applications in extreme environments.
Nan He +10 more
doaj +1 more source
International Journal of Renewable Energy DevelopmentHydrogen is a promising renewable energy carrier and eco-friendly alternative to fossil fuels. Water-gas-shift reaction (WGSR) is commonly used to generate hydrogen from renewable biomass feedstocks.
Zulaicha Dwi Hastuti +9 more
doaj +1 more source
Discrete field theory: symmetries and conservation laws
, 2018 We present a general algorithm constructing a discretization of a classical field theory from a Lagrangian. We prove a new discrete Noether theorem relating symmetries to conservation laws and an energy conservation theorem not based on any symmetry ...
Skopenkov, Mikhail
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
A note on weak solutions of conservation laws and energy/entropy conservation
, 2017 A common feature of systems of conservation laws of continuum physics is that they are endowed with natural companion laws which are in such case most often related to the second law of thermodynamics.
Gwiazda, Piotr +2 more
core +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
International Journal of Renewable Energy DevelopmentMicrogrid systems are part of the most reliable energy supply technologies for rural communities that do not have access to electricity but the system is generally dominated by diesel generators (DG).
Adinda Prawitasari +8 more
doaj +1 more source
Solutions to Cosmological Problems with Energy Conservation and Varying c, G and Lambda
, 2000 The flatness and cosmological constant problems are solved with varying speed of light c, gravitational coupling strength G and cosmological parameter Lambda, by explicitly assuming energy conservation of observed matter.
Albrecht A. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source