Results 71 to 80 of about 8,610,041 (309)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Simulation for the Effects of Well Pressure and Initial Temperature on Methane Hydrate Dissociation
Energies, 2018 Methane hydrate dissociation is a process of heat and mass transfer, and pressure and temperature are the most important parameters. The influence of pressure and temperature on the hydrate dissociate relationship between the two parameters is the ...
Minghao Yu +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular clustering unlocks high-performance hydrovoltaics across temperatures from −35 °C to 80 °C
Nature CommunicationsHydrovoltaic technologies face challenges of low conversion efficiency and narrow operational temperature ranges, limiting their practical applications in extreme environments.
Nan He +10 more
doaj +1 more source
International Journal of Renewable Energy DevelopmentHydrogen is a promising renewable energy carrier and eco-friendly alternative to fossil fuels. Water-gas-shift reaction (WGSR) is commonly used to generate hydrogen from renewable biomass feedstocks.
Zulaicha Dwi Hastuti +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Results in EngineeringPhotovoltaic (PV) cleaning is crucial to maintain optimal Performance Ratio (PR) in PV systems. PR is a key metric for acceptance tests and operations.
Oo Abdul Rosyid +9 more
doaj +1 more source