Results 61 to 70 of about 8,610,041 (309)

Pore‐Scale Intermittent Flow and Its Impact on Two‐Phase Fluid Distribution in Porous Media

open access: yesWater Resources Research
Understanding two‐phase flow in porous media is essential for optimizing subsurface storage efficiency. Pore‐scale flow properties significantly influence macroscopic plume migration behavior and trapping performance.
Xin Wang   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Effect of confining pressure on mechanical behavior of methane hydrate-bearing sediments

open access: yesPetroleum Exploration and Development, 2011
Synthesized gas hydrate in lab was mixed with kaoline to form core samples, so as to simulate the hydrate-bearing sedimentary layers in the seabed. Under conditions of different confining pressure, triaxial compressive tests were conducted on hydrate ...
Yanghui Li   +4 more
doaj   +1 more source

A hydrate blockage detection apparatus for gas pipeline using ultrasonic focused transducer and its application on a flow loop

open access: yesEnergy Science & Engineering, 2020
This paper introduces a novel apparatus and the analyzing method for hydrate blockage detection in natural gas pipeline using the ultrasonic focused testing technique.
Xingbo Li   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Strong tough hydrogel solar evaporator with wood skeleton construction enabling ultra‐durable brine desalination

open access: yesEcoMat, 2023
Hydrogels, a highly versatile material platform, are poised to become a promising candidate for interfacial solar evaporators on account of their record‐high evaporation rates.
Lin Li   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Behavioral Economics and Energy Conservation – A Systematic Review of Non-price Interventions and Their Causal Effects

open access: yesEcological Economics, 2018
Research from economics and psychology suggests that behavioral interventions can be a powerful climate policy instrument. This paper provides a systematic review of the existing empirical evidence on non-price interventions targeting energy conservation
Mark A. Andor, K. Fels
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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