Results 81 to 90 of about 1,377,021 (288)
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Results in EngineeringPhotovoltaic (PV) cleaning is crucial to maintain optimal Performance Ratio (PR) in PV systems. PR is a key metric for acceptance tests and operations.
Oo Abdul Rosyid +9 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Creep Behaviors of Methane Hydrate-Bearing Frozen Sediments
Energies, 2019 Creep behaviors of methane hydrate-bearing frozen specimens are important to predict the long-term stability of the hydrate-bearing layers in Arctic and permafrost regions.
Yanghui Li +5 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Experimental Study of Spray Characteristics of Kerosene-Ethanol Blends from a Pressure-Swirl Nozzle
International Journal of Aerospace Engineering, 2018 Partial replacement of kerosene by ethanol in a gas turbine is regarded as a good way to improve the spray quality and reduce the fossil energy consumption.
Tao Zhang +5 more
doaj +1 more source
Study on circuit breaker TRV issues of UHV high series compensation lines
The Journal of Engineering, 2019 Under the influence of series compensation (SC) capacitance and rated voltage rise, when ultra high voltage (UHV) high SC line occurs inner fault, the short-circuit current through the SC line is greater and the residual voltage across the SC is higher ...
Bin Zheng +5 more
doaj +1 more source
Quantum Measurements, Energy Conservation and Quantum Clocks
, 2017 We consider a spin chain extending from Alice to Bob with next neighbors interactions, initially in its ground state. Assuming that Bob measures the last spin of the chain, the energy of the spin chain has to increase, at least on average, due to the ...
Cruzeiro, Emmanuel Zambrini +1 more
core +2 more sources
Arthritis Care &Research, Accepted Article.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source