Results 101 to 110 of about 3,907,324 (294)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Energy vs. density on paths toward more exact density functionals [PDF]
Physical Chemistry Chemical Physics, 2018 The density-energy balance of density functionals is quantified using trial densities. Density errors commonly amount to only a few kJ mol−1.
openaire +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Investigation on space charge dynamics and mechanical properties of Epoxy Alumina nanocomposites
Materials Research Express, 2020 Epoxy nanocomposites with different wt% of alumina was prepared by use of high-speed shear mixer and high-frequency sonicator process, and the electrical and mechanical properties of the materials were investigated.
Neelmani +2 more
doaj +1 more source
Mass density vs. energy density at cosmological scales
Physics Letters BIn the presence of the gravitational field, the energy density of matter no longer coincides with its mass density. A discrepancy exists, of course, also between the associated power spectra. Within the $Λ$CDM model, we derive a formula that relates the power spectrum of the energy density to that of the mass density and test it with the help of N-body
Eingorn, Maxim +3 more
openaire +6 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Critical Point Fluctuations in Heavy-Ion Collisions within Molecular Dynamics with Expansion [PDF]
EPJ Web of ConferencesWe analyze particle number fluctuations near the critical endpoint of a first-order phase transition using molecular dynamics simulations of the Lennard-Jones fluid. Building on our previous study [V.A. Kuznietsov et al., Phys. Rev. C 105, 044903 (2022)],
Kuznietsov Volodymyr A. +3 more
doaj +1 more source
Kinetic Energy Density Study of Some Representative Semilocal Kinetic Energy Functionals
, 2007 There is a number of explicit kinetic energy density functionals for non-interacting electron systems that are obtained in terms of the electron density and its derivatives. These semilocal functionals have been widely used in the literature.
Atkins P. W. +11 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
All-optical structuring of laser-driven proton beam profiles
Nature Communications, 2018 Shaping particle beams generated from laser-plasma accelerators is challenging. Here the authors demonstrate an all-optical method to structure the accelerated proton beam by modulating and imprinting the spatial laser profile onto the proton beam.
Lieselotte Obst-Huebl +25 more
doaj +1 more source