Results 81 to 90 of about 3,552,792 (348)
Revista Ingeniería de Construcción, 2015 En la Antártica, un continente sensible a las actividades humanas y un lugar estratégico para la investigación de los efectos producidos por el cambio climático, es importante que los proyectos desarrollados ahí minimicen su impacto medioambiental.
Isabel Miño +2 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Increasing the Voltage—Sequencing Decarbonisation with Green Power and Efficiency
EnergiesThe industrial sector’s increasing electricity demand (direct and indirect), driven by the electrification of processes and the production of green hydrogen, poses significant challenges for achieving decarbonisation goals.
Stefan M. Buettner +5 more
doaj +1 more source
Iso-energy-efficiency: An approach to power-constrained parallel computation [PDF]
, 2010 Future large scale high performance supercomputer systems require high energy efficiency to achieve exaflops computational power and beyond. Despite the need to understand energy efficiency in high-performance systems, there are few techniques to ...
Ge, Rong +4 more
core +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
Personal Climatization Systems—A Review on Existing and Upcoming Concepts
Applied Sciences, 2018 To accomplish the current climate goals of the federal republic of Germany, energy efficiency within the building and automotive sector must improve considerably. One possible way to reduce the high amount of energy required for heating, ventilation, and
Alexander Warthmann +3 more
doaj +1 more source
Mechanism Design Approach for Energy Efficiency
, 2016 In this work we deploy a mechanism design approach for allocating a divisible commodity (electricity in our example) among consumers. We consider each consumer with an associated personal valuation function of the energy resource during a certain time ...
Bistarelli, Stefano +3 more
core
, 2013 The generation and conduction of action potentials represents a fundamental means of communication in the nervous system, and is a metabolically expensive process.
Liu, Liwei, Yu, Lianchun
core +1 more source