Results 91 to 100 of about 9,995,212 (291)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Business and industry e, energy, resources

, 2005
Title from p. [1] of PDF (viewed Mar. 13, 2006).; "Created: 9/7/2005...; Modified 9/21/2005"--Document properties screen.; Designed to be printed on one sheet, front and back, and then folded into a pamphlet.; Harvested from the web on 3/14/06Lists low ...
Ohio. Office of Energy Efficiency.
core  

Understanding the Energy Efficiency Operational Indicator: An empirical analysis of ships from the Royal Belgian Shipowners' Association [PDF]

, 2015
This paper explores the determinants of the Energy Efficiency Operational Indicator (EEOI1) by decomposing the indicator into sub-indices that reflect the technical characteristics and logistics of ships.
Smith, TWP, Laffineur, L, Raucci, C, Parker, S   +3 more
core  

Towards Greater Energy Efficiency in Latin America and the Caribbean: Progress and Policies

, 2019
Energy efficiency is the best tool to improve sustainability and affordability of energy services. However, there are considerable challenges when it comes to identifying opportunities and measurement.
Inter-American Development Bank
core   +1 more source

Research on Redundancy under Optimal Distribution Network Operation Efficiency Planning

Journal of Harbin University of Science and Technology
To address the issue of investment redundancy in traditional power distribution network planning, which often relies on extreme operational scenarios, this study proposes a distribution network planning method with operational efficiency as the core ...
JIN Panlong, CHE Bin, ZHANG Weiqi, QI Caijuan, JIANG Junjie   +4 more
doaj   +1 more source

Energy Efficiency Operational Indicator of the Selected Type of Polish Fleet Fishing Cutter in Dependence of the Main Engine Type

Journal of Physics: Conference Series, 2019
In view of the hazards to the environment, special areas were designated and named the Emission Control Areas (ECAs) and an energy efficiency of fishing cutters, this paper presents and comprises an analysis of the Energy Efficiency Operational Indicators' (EEOI) calculation results as an indicator relating fuel consumption and the emission of CO2 as a
openaire   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Methodology for assessing cost of electricity for energy community members

Energy Conversion and Management: X
Having achieved a significant share of renewable generation in different sectors of society, forming Energy Communities (EC) is the next step towards energy sustainability. The energy and economic performance of EC depends on several factors.
Elisa Peñalvo-López, Iván Valencia-Salazar, Vicente León-Martínez, Clara Inés Buriticá-Arboleda   +3 more
doaj   +1 more source