Results 101 to 110 of about 9,514,609 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A comprehensive indicator set for measuring multiple benefits of energy efficiency

, 2020
In this paper, we develop a quantitative indicator approach including 20 indicators to measure the multiple benefits of energy efficiency (MB-EE). The MB-EEs are classified into three groups: environmental (e.g. energy savings, emissions), economic (e.g.
Eichhammer, Wolfgang, Lapillonne, Bruno, Reuter, Matthias, Patel, Martin K., Pollier, Karine, Patel, Martin   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Methodology for assessing cost of electricity for energy community members

Energy Conversion and Management: X
Having achieved a significant share of renewable generation in different sectors of society, forming Energy Communities (EC) is the next step towards energy sustainability. The energy and economic performance of EC depends on several factors.
Elisa Peñalvo-López, Iván Valencia-Salazar, Vicente León-Martínez, Clara Inés Buriticá-Arboleda   +3 more
doaj   +1 more source

Energy efficiency estimation of a steam powered LNG tanker using normal operating data

MATEC Web of Conferences, 2016
A ship’s energy efficiency performance is generally estimated by conducting special sea trials of few hours under very controlled environmental conditions of calm sea, standard draft and optimum trim.
Sinha Rajendra Prasad
doaj   +1 more source

Energy Efficiency Board 2017 programs and operations report.

, 2018
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

How Vacancy of Dwellings Influences Energy Renovations of Multifamily Buildings

Energies
The European climate change mitigation agenda aims to decarbonise all buildings by 2050. However, many existing buildings may not remain operational by this time due to rapid urbanisation and population decline in various regions of Europe, potentially ...
Lauri Lihtmaa, Targo Kalamees
doaj   +1 more source

Federal energy efficiency and water conservation funding study

, 1998
This report contains the results of a study required by section 162 of the Energy Policy Act of 1992 (EPAct). It outlines options for financing energy and water conservation measures at Federal facilities as required by Part 3 of Title V of the National ...

core   +1 more source