Results 91 to 100 of about 1,149,935 (314)

Preparing for Connecticut's energy future : a report by the Connecticut Academy of Science and Engineering.

, 2008
"The Connecticut Clean Energy Fund (CCEF), on behalf of the Renewable Energy Investment Board (REIB), contracted with the Connecticut Academy of Science and Engineering (CASE) to conduct this study as directed by Public Act 08-168, An Act Concerning ...
Connecticut Academy of Science and Engineering. Study Committee on Preparing for Connecticut's Energy Future,
core  

Quantifying the accelerated diffusion and cost savings of global solar photovoltaic supply chains

iScience
Summary: Solar photovoltaic (PV) is critical for achieving the 2030 global target of tripling renewable power capacity. Over the past two decades, the global supply chain has significantly reduced the cost of solar PV products enabling widespread ...
Zhuo Chen, Baihe Gu, Donghui Yu, Chen Wang   +3 more
doaj   +1 more source

Photoexcitation dynamics and energy engineering in supramolecular doping of organic conjugated molecules. [PDF]

Light Sci Appl, 2023
An X, Wei C, Bai L, Zhou J, Wang L, Han Y, Sun L, Lin J, Liu H, Li J, Xu M, Ling H, Xie L, Huang W.   +13 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A review on the progress and research directions of ocean engineering

, 2023
This paper reviews research in ocean engineering over the last 50+ years with the aim to (I) understand the technological challenges and evolution in the field, (II) investigate whether ocean engineering studies meet present global demands, (III) explore
Hirdaris, Spyros, Spyros Hirdaris, Sasan Tavakoli, Tavakoli, Sasan, Haghani, Milad, Khojasteh, Danial, Milad Haghani, Danial Khojasteh   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Accelerating ASEAN’s energy transition in the power sector through cross-border transmission and a net-zero 2050 view

iScience
Summary: Faced with energy transition objectives, the ten countries of the Association of Southeast Asian Nations (ASEAN) have technology options to decarbonize power sector.
Sheng Zhong, Lingyi Yang, Dimitri J. Papageorgiou, Bin Su, Tsan Sheng Ng, Saifudin Abubakar   +5 more
doaj   +1 more source