Results 111 to 120 of about 7,363,445 (247)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Moving Toward Zero Energy Homes. Armory Park del Sol, Tucson, Arizona

, 2003
Zero energy home fact sheets available for other places from http://www.eere.energy.gov/buildings/building_america/publications ...
United States Department of Energy; Office of Energy Efficiency and Renewable Energy
core  

Ameliorating and Tailoring the Morphological and Optical Properties of PEO-MnO2-SrTiO3 Solid State Nanocomposites for Electronics Fields

Фізика і хімія твердого тіла
In this work, polymer nanocomposites films of (PEO-MnO2-SrTiO3) were manufactured using the casting method, where varying percentages of nanoparticles (MnO2-SrTiO3) were mixed at concentrations of 1.7%, 3.4%, and 5.1%, respectively. The morphological and
M.H. Abbas, Saif H. Hameed, Ahmed Hashim
doaj   +1 more source

Excitations in a superconducting Coulombic energy gap. [PDF]

Nat Commun, 2022
Estrada Saldaña JC, Vekris A, Pavešić L, Krogstrup P, Žitko R, Grove-Rasmussen K, Nygård J.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Orbital Shift-Induced Boundary Obstructed Topological Materials with a Large Energy Gap. [PDF]

Adv Sci (Weinh), 2022
Mao N, Li R, Dai Y, Huang B, Yan B, Niu C.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Magnetic field effects on the crystal structure, morphology, energy gap, and magnetic properties of manganese selenide nanoparticles synthesized by hydrothermal method. [PDF]

Nanoscale Adv, 2023
Nokabadi AS, Yazdani A.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source