Results 81 to 90 of about 1,130,906 (218)

Experimental Study on flow Resistance in Compound Channelswith Totally Mobile Bed

工程科学与技术, 2007
:Understanding flow resistance in a compound channel with totally mobile bed is important for determining the stage discharge curve and supporting the management of fluvial processes.
doaj  

Energy Loss Analysis at the Gland Seals of a Marine Turbo-Generator Steam Turbine

Tehnički Glasnik, 2020
The paper presents an analysis of marine Turbo-Generator Steam Turbine (TGST) energy losses at turbine gland seals. The analyzed TGST is one of two identical Turbo-Generator Steam Turbines mounted in the steam propulsion plant of a commercial LNG carrier.
Lino Kocijel, Igor Poljak, Vedran Mrzljak, Zlatan Car   +3 more
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

New characteristic parameter of energy loss in permalloy

New Journal of Physics
Characteristic parameters of energy storage and loss in soft magnetic materials (SMMs), product S of initial susceptibility $ \chi_\mathrm{i} $ and resonance frequency $ \omega_\mathrm{r} $ and product L of maximum $ \chi_\mathrm{m}^{^{\prime\prime ...
Tong Li, Dezheng Yang, Xiaowei Jin, Li Xi, Desheng Xue   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Reduction of Magnetizing Inrush Current in Traction Electric Network Based on Virtual Centrifugal Switch

Kongzhi Yu Xinxi Jishu, 2019
Inrush current may reduce the reliability of traction transformer protection device and it can be suppressed by adopting series external resistor. After traction electric network comes back to normal, it needs to short the resistor quickly.
HUANG Zhixiong, YANG Gang, LI Zhiyong, XI Kailong   +3 more
doaj  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source