Results 71 to 80 of about 8,597,032 (385)
Scaling of brain metabolism and blood flow in relation to capillary and neural scaling [PDF]
PLoS ONE 6(10): e26709 (2011), 2011 Brain is one of the most energy demanding organs in mammals, and its total metabolic rate scales with brain volume raised to a power of around 5/6. This value is significantly higher than the more common exponent 3/4 relating whole body resting metabolism with body mass and several other physiological variables in animals and plants.
arxiv +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Insights into muscle metabolic energetics: Modelling muscle-tendon mechanics and metabolic rates during walking across speeds [PDF]
arXiv, 2023 Prior studies have produced models to predict metabolic rates based on experimental observations of isolated muscle contraction from various species. Such models can provide reliable predictions of metabolic rates in humans if muscle properties and control are accurately modeled.
arxiv
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Cell Biology International, 2018 AMP‐activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy balance by decreasing the ATP‐consuming processes such as transcription of ...
R. Ke +4 more
semanticscholar +1 more source
SIRT1 and energy metabolism [PDF]
Acta Biochimica et Biophysica Sinica, 2013 Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety ...
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Activity-dependent glassy cell mechanics II: Non-thermal fluctuations under metabolic activity [PDF]
arXiv, 2023 The glassy cytoplasm, crowded with bio-macromolecules, is fluidized in living cells by mechanical energy derived from metabolism. Characterizing the living cytoplasm as a non-equilibrium system is crucial in elucidating the intricate mechanism that relates cell mechanics to metabolic activities.
arxiv
, 2023 The processes of renewal of cellular structures, enzymes, plasma proteins, hormones, etc. are constantly going on in the body. Renewal is associated with the breakdown of organic compounds (catabolism) and the synthesis of newly formed substances (anabolism).
openaire +2 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Patterns of Selection of Human Movements I: Movement Utility, Metabolic Energy, and Normal Walking Gaits [PDF]
, 2016 The biomechanics of the human body allow humans a range of possible ways of executing movements to attain specific goals. Nevertheless, humans exhibit significant patterns in how they execute movements. We propose that the observed patterns of human movement arise because subjects select those ways to execute movements that are, in a rigorous sense ...
arxiv +1 more source