Results 51 to 60 of about 7,366,329 (309)

The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity

, 2021
Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue accompanied with alterations in the immune and metabolic responses.
Pei-Chi Chan, Po-Shiuan Hsieh
core   +1 more source

Current status of traditional Chinese medicine in modulating mitochondrial metabolic abnormalities in tumors

Cancer Biology & Medicine
Tumor cells undergo metabolic reprogramming to adapt to rapid proliferation and harsh microenvironments, as evidenced by aerobic glycolysis. Mitochondria serve as key coordinators of this process.
Siyi Ma, Jiarong Li, Bingjie Hao, Lihong Fan   +3 more
doaj   +1 more source

Brain Regulation of Energy Metabolism [PDF]

Endocrinology and Metabolism, 2016
In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity.
Eun Roh, Min-Seon Kim
doaj   +1 more source

Blood Levels of Neuropeptide 26RFa in Relation to Anxiety and Aggressive Behavior in Humans—An Exploratory Study

Brain Sciences, 2023
26RFa, also referred to as QRFP, is a hypothalamic neuropeptide mainly known for its role in the regulation of appetite and glucose metabolism. Its possible relevance to emotional regulation is largely unexplored.
Henning Værøy, Saloua Takhlidjt, Yamina Cherifi, Emilie Lahaye, Nicolas Chartrel, Serguei O. Fetissov   +5 more
doaj   +1 more source

SIRT1 and energy metabolism [PDF]

Acta Biochimica et Biophysica Sinica, 2013
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety ...
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review [PDF]

, 2023
This comprehensive narrative review explores the concept of neuro-vulnerability in energy metabolism regulation and its implications for metabolic disorders.
Beltrán Velasco, Ana Isabel, Redondo-Flórez, Laura, Beltrán-Velasco, Ana Isabel, Yáñez Sepúlveda, Rodrigo, Vicente Javier Clemente-Suárez, Rodrigo Yáñez-Sepúlveda, Martín Rodríguez, Alexandra, Alexandra Martín-Rodríguez, José Francisco Tornero-Aguilera, Clemente Suárez, Vicente Javier, Redondo Flórez, Laura, Clemente-Suárez, Vicente Javier, Ana Isabel Beltrán-Velasco, Tornero Aguilera, José Francisco, Martín-Rodríguez, Alexandra, Yáñez-Sepúlveda, Rodrigo, Tornero-Aguilera, José Francisco, Laura Redondo-Flórez   +17 more
core   +1 more source

PI3K/AKT/mTOR pathway and c-Myc inhibit hepatocyte suspension under simulated microgravity

npj Microgravity
Microgravity affects cell growth and apoptosis. Using a random positioning machine, we previously found that simulated microgravity (SMG) suppresses total cell proliferation and induces apoptosis of in vitro cultured hepatocytes.
Yue Xiong, Chiyuan Ma, Jingtong Xie, Zekai Chen, Ke Zhang, XiaoHua Lei   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source