Results 71 to 80 of about 6,255,996 (283)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Global existence and decay estimates of the classical solution to the compressible Navier-Stokes-Smoluchowski equations in ℝ3

Advances in Nonlinear Analysis
The compressible Navier-Stokes-Smoluchowski equations under investigation concern the behavior of the mixture of fluid and particles at a macroscopic scale. We devote to the existence of the global classical solution near the stationary solution based on
Tong Leilei
doaj   +1 more source

Studying High Energy Final State Interactions by N/D Method

, 1999
We discuss the final state interaction effects at high energies via a multi-channel N/D method. We find that the 2 by 2 charge--exchange final state interactions typically contribute an enhancement factor of a few times $10^{-2}$ in the $B$ meson decay ...
Cahn R N, Goldberger M, Gronau M, Suzuki M, Yuan Feng, Zheng Han-Qing   +5 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Numerical and Experimental Study on Dummy Blade with Underplatform Damper

Machines
To confirm the variation in damping ratio offered by dry friction dampers against structural vibration stress, this study developed a blade vibration response test system for capturing damping characteristic curves through both frequency sweep excitation
Di Li, Chenhong Du, Hongguang Li, Guang Meng   +3 more
doaj   +1 more source

Mechanic properties analysis of quasi-square honeycomb sandwich structure′s core

Journal of Hebei University of Science and Technology, 2017
In order to illustrate the relationship between the quasi-square-honeycomb structure and the hexagonal honeycomb structure, after decomposing the quasi-square honeycomb sandwich structure into unique T-shaped cell, the equivalent elastic constants ...
Guan TONG, Xiang LI, Yueyuan MEI, Youhui ZHOU   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Casimir Energy for a Purely Dielectric Cylinder by the Mode Summation Method

, 2005
We use the mode summation method together with zeta-function regularization to compute the Casimir energy of a dilute dielectric cylinder. The method is very transparent, and sheds light on the reason the resulting energy vanishes.Comment: 11 pages ...
August Romeo, Barton, Beneventano, Bordag, Brevik, Cavero-Peláez, Cognola, Fulling, Gradshteyn, Graham, Kimball A. Milton, Klich, Klich, Lambiase, Milton, Milton, Stratton, van Kampen   +17 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source