Results 61 to 70 of about 125,121 (265)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Energy Modelling as a Trigger for Energy Communities: A Joint Socio-Technical Perspective

Energies, 2020
Mainstreaming energy communities has been one of the main challenges in the low-carbon transition of cities. In this sense, urban building energy modelling (UBEM) has an untapped role in enabling energy communities, as simulations on urban models provide
Viktor Bukovszki, Ábel Magyari, Marina Kristina Braun, Kitti Párdi, András Reith   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A distributed architecture for MQTT messaging: the case of TBMQ

Journal of Big Data
This article introduces ThingsBoard Message Queue (TBMQ), a scalable and fault-tolerant Message Queuing Telemetry Transport (MQTT) broker designed to address the challenges of data handling in large-scale Internet of Things (IoT) ecosystems.
Andrii Shvaika, Dmytro Shvaika, Dmytro Landiak, Volodymyr Artemchuk   +3 more
doaj   +1 more source

Spatial and Temporal Analysis on the Distribution of Active Radio-Frequency Identification (RFID) Tracking Accuracy with the Kriging Method

Sensors, 2014
Radio frequency identification (RFID) technology has already been applied in a number of areas to facilitate the tracking process. However, the insufficient tracking accuracy of RFID is one of the problems that impedes its wider application.
Xin Liu, Jeremy Shannon, Howard Voun, Martijn Truijens, Hung-Lin Chi, Xiangyu Wang   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Long-Term Forecasting: A MAED Application for Sierra Leone’s Electricity Demand (2023–2050)

Energies
Sierra Leone is an electricity-poor country with one of the lowest electricity consumption per capita rates across sub-Saharan Africa. Yet, with ambitious targets to transform and stimulate its economy in the coming decades, energy demand forecasting ...
Neve Fields, William Collier, Fynn Kiley, David Caulker, William Blyth, Mark Howells, Ed Brown   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source