Results 51 to 60 of about 189,310,264 (260)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Bond Graph Based Stability Analysis of a Railway Traction System [PDF]

, 2005
This paper emphasises the interest of the Bond Graph approach for analysis and system design of heterogeneous and multi-field devices. In particular, the local stability analysis of non linear systems can be directly derived from the linearised Causal ...
Sareni, Bruno, Gandanegara, Grace, Roboam, Xavier, Dauphin-Tanguy, Geneviève   +3 more
core  

Bond graph analysis in robust engineering design [PDF]

, 2000
Within engineering design, optimization often involves building models of working systems to improve design objectives such as performance, reliability and cost.
GABBRIELLI R., de Mast, J., Does, R.J.M.M., BRAGLIA, MARCELLO, van den Heuvel, E.R., BRAGLIA M., Heuvel, van den, E.R., Bates, RA, YANG, Zhenlin, BEVILACQUA M., Atherton, MA, GABBRIELLI, ROBERTO, Bates, R. A., Yang, Z., Schippers, W.A.J., Atherton, M. A., Mast, de, J., Does, R.J.M.M.; id_orcid, BEVILACQUA, MAURIZIO, Wu, Shuo-jye; Tsai, Tzong-ru, Xie, M., Gaudoin, O., Wu, Shuo-jye   +22 more
core   +1 more source

Relation Between Randic and Harmonic Energies of Commuting Graph for Dihedral Groups

Science and Technology Indonesia
Consider a finite group G with center Z(G). This work examines the commuting graph $\Gamma_G$, a graph constructed from a group $G$ whose vertices correspond precisely to the noncentral elements of the group, that is, all elements in $G$ except those ...
Mamika Ujianita Romdhini, Athirah Nawawi   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Resource of the National Action Plan for Energy Efficiency [PDF]

, 2009
This brief documents how energy efficiency program administrators have used technical, institutional, financial, and other resources to help advance building energy codes at the federal, state, and local levels, and describes the issues involved in ...
National Action Plan for Energy Efficiency, National Action Plan for Energy Efficiency (U.S.)   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On distance Laplacian energy in terms of graph invariants

, 2023
summary:For a simple connected graph $G$ of order $n$ having distance Laplacian eigenvalues $ \rho ^{L}_{1}\geq \rho ^{L}_{2}\geq \cdots \geq \rho ^{L}_{n}$, the distance Laplacian energy ${\rm DLE} (G)$ is defined as ${\rm DLE} (G)=\sum _{i=1}^{n}|\rho ^
Rather, Bilal A., Ul Shaban, Rezwan, Ganie, Hilal A., Pirzada, Shariefuddin   +3 more
core   +1 more source

Some New Results on Various Graph Energies of the Splitting Graph

Journal of Chemistry, 2019
The energy of a simple connected graph G is equal to the sum of the absolute value of eigenvalues of the graph G where the eigenvalue of a graph G is the eigenvalue of its adjacency matrix AG.
Zheng-Qing Chu, Saima Nazeer, Tariq Javed Zia, Imran Ahmed, Sana Shahid   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source