Results 61 to 70 of about 189,310,264 (260)

Graph kernel extensions and experiments with application to molecule classification, lead hopping and multiple targets

open access: yes, 2009
The discovery of drugs that can effectively treat disease and alleviate pain is one of the core challenges facing modern medicine. The tools and techniques of machine learning have perhaps the greatest potential to provide a fast and efficient route ...
Demco, Anthony A, Demco, Anthony A.
core   +1 more source

Some degree-based topological indices and (normalized Laplacian) energy of graphs [PDF]

open access: yesDiscrete Mathematics Letters, 2022
Zimo Yan, Xie Zheng, Jianping Li
doaj   +1 more source

The Degree Energy of a Graph

open access: yesMathematics
The incidence of edges on vertices is a cornerstone of graph theory, with profound implications for various graph properties and applications. Understanding degree distributions and their implications is crucial for analyzing and modeling real-world ...
A. R. Nagalakshmi   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Promotion of Efficient Use of Energy: Final Report

open access: yes, 2006
The Department of Energy funded the Alliance to Save Energy to promote the efficient use of energy under a multiyear cooperative agreement. This funding allowed the Alliance to be innovative and flexible in its program development, and to initiate and ...
Alliance to Save Energy (U.S.)
core   +1 more source

Forcing (G,D)-number of a Graph [PDF]

open access: yes, 2011
By a graph G=(V,E), we mean a finite, undirected connected graph without loops and multiple ...
Nagarajan, A.   +3 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Projected Benefits of Federal Energy Efficiency and Renewable Energy Programs: FY 2005 Budget Request

open access: yes, 2004
The Office of Energy Efficiency and Renewable Energy (EERE) of the U.S. Department of Energy (DOE) leads the Federal Government's efforts to provide reliable, affordable, and environmentally sound energy for America, through its 11 research, development,
Laboratory, National Renewable Energy
core   +1 more source

Relations between ordinary energy and energy of a self-loop graph

open access: yesHeliyon
Let G be a graph on n vertices with vertex set V(G) and let S⊆V(G) with |S|=α. Denote by GS, the graph obtained from G by adding a self-loop at each of the vertices in S.
B.R. Rakshith   +3 more
doaj   +1 more source

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