Results 71 to 80 of about 520,925 (264)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Impact on U.S. Industries of Carbon Prices with Output-Based Rebates over Multiple Time Frames [PDF]

The effects of a carbon price on U.S. industries are likely to change over time as firms and customers gradually adjust to new prices. The effects will also depend on the number of countries implementing the policy as well as offsetting policies to ...
Adkins, Liwayway, Morgenstern, Richard, Moore, Eric, Garbaccio, Richard, Ho, Mun   +4 more
core  

Do Real Output and Renewable Energy Consumption Affect CO2 Emissions? Evidence for Selected BRICS Countries

, 2020
Climate change is one of the most important global problems faced by the international community. It is generally believed that increasing the consumption of renewable energy is an effective measure to promote CO2 emissions reduction.
Chao-Qun Ma, Jiang-Long Liu, Xin-Wei Zhao, Yi-Shuai Ren   +3 more
core   +1 more source

Revealing An Intercalation-Conversion-Heterogeneity Hybrid Lithium-Ion Storage Mechanism in Transition Metal Nitrides Electrodes with Jointly Fast Charging Capability and High Energy Output. [PDF]

Adv Sci (Weinh), 2022
Li F, Li Y, Zhao L, Liu J, Zuo F, Gu F, Liu H, Liu R, Li Y, Zhan J, Li Q, Li H.   +11 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Policies for Carbon Energy Footprint Reduction of Overhead Multiple-Input Multiple-Output High Voltage Broadband over Power Lines Networks

, 2015
The impact of different environmental policies on the broadband performance of overhead multiple-input multiple-output high-voltage/broadband over power lines (MIMO/HV/BPL) networks is investigated in this paper.
Lazaropoulos, Athanasios G.
core   +1 more source

Metallic-Ion Controlled Dynamic Bonds to Co-Harvest Isomerization Energy and Bond Enthalpy for High-Energy Output of Flexible Self-Heated Textile. [PDF]

Adv Sci (Weinh), 2022
Wang H, Feng Y, Gao J, Fang W, Ge J, Yang X, Zhai F, Yu Y, Feng W.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Numerical Investigations on the Effect of Blade Angles of a Vertical Axis Wind Turbine on its Performance Output [PDF]

, 2015
There are many social, political and environmental issues associated with the use of fossil fuels. For this reason, there are numerous investigations currently being carried out to develop newer and renewable sources of energy to alleviate energy demand.
Park, Kyoo Seon, Park, Kyooseon, Park, Kyoo-seon, Asim, Taimoor, Mishra, Rakesh   +4 more
core