Results 61 to 70 of about 8,399,207 (351)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Analytical Model for the Impact of Building Control and Automation Upgrade on Space Heating Energy Efficiency

open access: yesBuildings, 2022
Intelligent building management systems are proven to lead to energy savings and are an integral component of smart buildings. The procedures developed in the EN standards describe the methodology for calculating the energy savings achieved by improving ...
Lina Morkunaite   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Energy Audit of a Fitness/Leisure Centre

open access: yesJournal of Sustainable Design and Applied Research in Innovative Engineering of the Built Environment, 2017
This paper aims to investigate the energy performance of a fitness/leisure centre. A detailed energy audit has been conducted to determine the energy consumption of the building.
Eoin D. McLean, Paul Wynne
doaj   +1 more source

Energy Efficiency and Feasibility Analysis of Solar Power Generation Using Hybrid System of an Educational Institution in Malaysia

open access: yesInternational Journal of Photoenergy, 2023
Energy is one of the basic inputs and driving forces for economic and social development modernization. Sustainable energy supply is one of the major challenges in the modern world.
Muhammad Firdaus Mohd Zublie   +2 more
doaj   +1 more source

Thermal performance analysis of near infra-red reflection and green roof cooling techniques on buildings made of mild steel

open access: yesRenewable Energy and Environmental Sustainability, 2023
This paper investigates the thermal performance of green roofs, cool roofs, and their combined effects in tropical climates. Although each technology has been studied independently for its potential to reduce cooling energy consumption in buildings ...
Mdlalose Nonkululeko Portia   +3 more
doaj   +1 more source

Effect of Night Blinds on Open Integral Display Cabinets [PDF]

open access: yes, 2004
The impact of night blinds on the product temperature performance and electrical energy consumption of an integral open multi-deck cabinet is investigated in this paper.
Datta, D, Tassou, S., Watkins, Richard
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Vehicle energy savings by optimizing road speed-sectioning

open access: yesEuropean Transport Research Review, 2020
In a context of decreasing resources and of climate change, lowering road vehicles consumption is a key point to meet CO2 reduction requirements. In addition to car technological advances, eco-driving is part of the solution but the road infrastructure ...
Alex Coiret   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy